Beneficial Effects of Dietary Flaxseed Oil through Inflammation Pathways and Gut Microbiota in Streptozotocin-Induced Diabetic Mice.

TLR4/MyD88 flaxseed oil gut microbiota hepatic inflammation type 1 diabetes

Journal

Foods (Basel, Switzerland)
ISSN: 2304-8158
Titre abrégé: Foods
Pays: Switzerland
ID NLM: 101670569

Informations de publication

Date de publication:
28 Aug 2023
Historique:
received: 31 07 2023
revised: 17 08 2023
accepted: 23 08 2023
medline: 9 9 2023
pubmed: 9 9 2023
entrez: 9 9 2023
Statut: epublish

Résumé

Flaxseed oil (FO) has displayed potential anti-diabetes properties by providing a high content of α-linolenic acid. However, the effects and mechanisms of FO on type 1 diabetes are still unclear. The present study aims to explore the effects of different doses of FO feeding on hepatic inflammation and gut microbiota in streptozotocin-induced diabetic mice. Forty-eight six-week-old C57BL/6J male mice were divided into a control group (CON), a diabetic group (MOD), a diabetes with 7.0%

Identifiants

pubmed: 37685162
pii: foods12173229
doi: 10.3390/foods12173229
pmc: PMC10487211
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : National Natural Science Foundation of China
ID : 82003457
Organisme : Jiangsu Province Science Foundation for Youths
ID : BK20200366
Organisme : Fundamental Research Funds for the Central Universities and "Zhishan" Scholars Programs of Southeast University
ID : NO. 2242021R40022

Références

PLoS One. 2021 Oct 19;16(10):e0258800
pubmed: 34665824
Nutr Hosp. 2015 Jun 01;31(6):2641-7
pubmed: 26040376
Scand J Clin Lab Invest. 2020 Oct;80(6):484-490
pubmed: 32644839
Inflammopharmacology. 2022 Feb;30(1):91-110
pubmed: 34997431
Nutr Metab Insights. 2022 Jun 29;15:11786388221090083
pubmed: 35799617
Br J Nutr. 2018 Jan;119(1):83-89
pubmed: 29355094
Public Health Nutr. 2014 Jul;17(7):1587-94
pubmed: 23866795
Hepatol Int. 2010 Oct 21;4(4):659-72
pubmed: 21286336
Diabetologia. 2021 May;64(5):1037-1048
pubmed: 33595677
J Physiol Biochem. 2016 Jun;72(2):327-36
pubmed: 27048415
Am J Clin Nutr. 2011 Aug;94(2):520-6
pubmed: 21593505
Am J Clin Nutr. 2023 Jan;117(1):130-140
pubmed: 36789932
J Food Sci Technol. 2014 Sep;51(9):1633-53
pubmed: 25190822
Food Sci Nutr. 2019 Nov 19;7(12):3873-3882
pubmed: 31890165
Arch Physiol Biochem. 2014 Feb;120(1):34-9
pubmed: 24320056
Am J Clin Nutr. 2003 Dec;78(6):1098-102
pubmed: 14668270
Lipids Health Dis. 2020 Feb 7;19(1):20
pubmed: 32028957
mSphere. 2021 Dec 22;6(6):e0085121
pubmed: 34851167
Int J Mol Sci. 2022 Sep 09;23(18):
pubmed: 36142393
Obes Surg. 2007 Mar;17(3):341-7
pubmed: 17546842
Diabetes Care. 2004 Oct;27(10):2563-4
pubmed: 15451940
Hum Exp Toxicol. 2015 Nov;34(11):1133-8
pubmed: 25669659
Int J Food Sci Nutr. 2021 May;72(3):386-390
pubmed: 32746658
J Am Coll Nutr. 2010 Feb;29(1):72-80
pubmed: 20595648
Lab Anim. 2015 Apr;49(1 Suppl):37-46
pubmed: 25835737
Br J Nutr. 1993 Mar;69(2):443-53
pubmed: 8098222
J Agric Food Chem. 2018 Oct 17;66(41):10729-10740
pubmed: 30145885
Nutrients. 2022 Mar 25;14(7):
pubmed: 35405981
Lancet Diabetes Endocrinol. 2020 Mar;8(3):226-238
pubmed: 31999944
Front Cardiovasc Med. 2022 Feb 28;9:830781
pubmed: 35295260
Iran J Basic Med Sci. 2019 Mar;22(3):255-261
pubmed: 31156785
Nat Rev Endocrinol. 2021 Mar;17(3):150-161
pubmed: 33293704
Appl Microbiol Biotechnol. 2017 Oct;101(20):7653-7662
pubmed: 28889199
Circulation. 2005 Nov 22;112(21):3232-8
pubmed: 16301356
J Nutr Biochem. 2019 Apr;66:52-62
pubmed: 30771734
Nat Rev Endocrinol. 2016 Mar;12(3):154-67
pubmed: 26729037
Free Radic Biol Med. 2021 Jan;162:53-64
pubmed: 33271280
Transl Res. 2016 Jan;167(1):214-27
pubmed: 25980926
mSystems. 2020 Nov 3;5(6):
pubmed: 33144308
Complement Ther Med. 2022 Nov;70:102852
pubmed: 35843472
Atherosclerosis. 2014 Sep;236(1):31-8
pubmed: 25014032
BMJ. 2019 Aug 21;366:l4697
pubmed: 31434641
Microorganisms. 2021 Jan 12;9(1):
pubmed: 33445500
Diabetes Care. 2008 Jan;31(1):93-5
pubmed: 17914029
Obesity (Silver Spring). 2006 Feb;14(2):295-300
pubmed: 16571856
Food Chem. 2013 Nov 1;141(1):187-95
pubmed: 23768346
Acta Pharmacol Sin. 2021 Oct;42(10):1610-1619
pubmed: 33495514
BMJ. 2004 Jan 3;328(7430):30-5
pubmed: 14703544
J Bioenerg Biomembr. 2020 Dec;52(6):421-430
pubmed: 33156468
Eur Heart J. 2011 Oct;32(20):2573-84
pubmed: 21285075
J Diet Suppl. 2016;13(3):339-51
pubmed: 26317558
Nutrients. 2022 Sep 10;14(18):
pubmed: 36145115
Diabetes Metab Res Rev. 2001 Sep-Oct;17(5):380-6
pubmed: 11747143
Vasa. 2013 Nov;42(6):421-8
pubmed: 24220118

Auteurs

Hui Xia (H)

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Ying Wang (Y)

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Xiangling Shi (X)

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Wang Liao (W)

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Shaokang Wang (S)

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Jing Sui (J)

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Research Institute for Environment and Health, Nanjing University of Information Science and Technology, Nanjing 211544, China.

Guiju Sun (G)

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Classifications MeSH