SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications.
SMAD
cancer
diagnosis
transforming growth factor-β
treatment
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
26 Aug 2023
26 Aug 2023
Historique:
received:
08
07
2023
revised:
17
08
2023
accepted:
25
08
2023
medline:
9
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway. The TGF-β pathway is widely known for its dual role in cancer progression as both an inhibitor of tumour cell growth and an inducer of tumour metastasis. This is mainly mediated through SMAD proteins and their cofactors or regulators. SMAD proteins act as transcription factors, regulating the transcription of a wide range of genes, and their rich post-translational modifications are influenced by a variety of regulators and cofactors. The complex role, mechanisms, and important functions of SMAD proteins in tumours are the hot topics in current oncology research. In this paper, we summarize the recent progress on the effects and mechanisms of SMAD proteins on tumour development, diagnosis, treatment and prognosis, and provide clues for subsequent research on SMAD proteins in tumours.
Identifiants
pubmed: 37685308
pii: diagnostics13172769
doi: 10.3390/diagnostics13172769
pmc: PMC10487229
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 81572783
Organisme : National Natural Science Foundation of China
ID : 81974438
Organisme : National Natural Science Foundation of China
ID : 82173069
Organisme : Zhejiang Provincial Natural Science Foundation
ID : LQ23C060003
Organisme : Zhejiang Medicine and Health Science and Technology Project
ID : 2023KY124
Références
Cancer Res. 1996 Oct 1;56(19):4351-3
pubmed: 8813122
Exp Mol Med. 2023 May;55(5):952-964
pubmed: 37121971
Mol Oncol. 2020 Apr;14(4):808-828
pubmed: 31925912
Gastroenterology. 2022 Nov;163(5):1334-1350.e14
pubmed: 35863523
Front Oncol. 2021 Oct 04;11:728583
pubmed: 34671554
Cell Death Dis. 2020 Dec 7;11(12):1038
pubmed: 33288752
EBioMedicine. 2020 Dec;62:103108
pubmed: 33186807
Oncol Res. 2022 Aug 31;29(4):263-273
pubmed: 37303938
Oncogene. 2020 Jun;39(23):4538-4550
pubmed: 32372060
J Proteome Res. 2023 Jan 6;22(1):138-151
pubmed: 36450103
J Exp Clin Cancer Res. 2022 Feb 10;41(1):59
pubmed: 35144669
Oncol Lett. 2020 May;19(5):3506-3512
pubmed: 32269624
Pharm Biol. 2022 Dec;60(1):1865-1875
pubmed: 36205544
Cell Mol Gastroenterol Hepatol. 2021;12(2):689-713
pubmed: 33774196
Aging (Albany NY). 2019 May 31;11(10):3298-3314
pubmed: 31147529
Ann Oncol. 2004 Apr;15(4):574-80
pubmed: 15033661
EMBO J. 2001 Aug 1;20(15):4132-42
pubmed: 11483516
Biol Chem. 2021 Jan 18;402(4):469-480
pubmed: 33938174
Eur J Pharmacol. 2023 May 15;947:175678
pubmed: 36990262
Gastroenterology. 2020 Jan;158(1):238-252
pubmed: 31585122
J Exp Clin Cancer Res. 2019 Apr 12;38(1):159
pubmed: 30979374
Mol Biol Rep. 2020 Jul;47(7):5033-5040
pubmed: 32507921
Cell Death Discov. 2022 Apr 13;8(1):199
pubmed: 35418191
Mol Biol Cell. 2006 Sep;17(9):3819-31
pubmed: 16775010
Front Cell Dev Biol. 2022 May 03;10:850708
pubmed: 35592246
Cancer Sci. 2019 May;110(5):1676-1685
pubmed: 30838724
Oncogenesis. 2017 Jan 30;6(1):e294
pubmed: 28134936
Comput Struct Biotechnol J. 2022 Mar 02;20:1154-1167
pubmed: 35317237
Nat Commun. 2022 Sep 20;13(1):5506
pubmed: 36127339
J Cell Mol Med. 2020 Dec;24(24):14539-14548
pubmed: 33174391
Phytother Res. 2023 May;37(5):1771-1786
pubmed: 36444395
Oncogene. 2010 Mar 4;29(9):1351-61
pubmed: 20010874
Cell Oncol (Dordr). 2022 Aug;45(4):573-589
pubmed: 35716259
Genes Dev. 1998 Jul 15;12(14):2153-63
pubmed: 9679060
J Clin Lab Anal. 2018 Jan;32(1):
pubmed: 28374902
J Transl Med. 2022 Feb 5;20(1):75
pubmed: 35123494
Gastric Cancer. 2016 Jan;19(1):198-205
pubmed: 25616808
Transl Res. 2019 Feb;204:72-81
pubmed: 30342000
Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):29-40
pubmed: 16289860
J Natl Cancer Inst. 2014 Feb;106(2):djt369
pubmed: 24511106
Exp Hematol Oncol. 2021 Feb 23;10(1):17
pubmed: 33622411
Cell Rep. 2022 Jul 26;40(4):111066
pubmed: 35905726
BMB Rep. 2019 Feb;52(2):139-144
pubmed: 30545440
Bioengineered. 2021 Dec;12(1):2534-2549
pubmed: 34138687
Cell. 1999 Apr 2;97(1):29-39
pubmed: 10199400
Arch Biochem Biophys. 2023 Jul 1;742:109620
pubmed: 37142077
Clin Cancer Res. 2019 Oct 1;25(19):5843-5851
pubmed: 31221662
J Biol Chem. 1999 Dec 3;274(49):35269-77
pubmed: 10575014
Mol Cancer. 2022 Feb 8;21(1):41
pubmed: 35135542
Cell Death Differ. 2022 Apr;29(4):818-831
pubmed: 34799729
J Clin Invest. 2013 Jul;123(7):2832-49
pubmed: 23921128
Sci Bull (Beijing). 2020 May 30;65(10):842-853
pubmed: 36659203
Adv Sci (Weinh). 2021 Feb 24;8(10):2003047
pubmed: 34026434
Trends Cancer. 2017 Jan;3(1):56-71
pubmed: 28718426
Oncogene. 2021 Apr;40(14):2539-2552
pubmed: 33686239
Nucleic Acids Res. 2023 Apr 11;51(6):2655-2670
pubmed: 36727462
Cancer Res. 2020 Jan 15;80(2):276-290
pubmed: 31694906
Cell. 2003 Jun 13;113(6):685-700
pubmed: 12809600
Appl Biochem Biotechnol. 2022 Nov 24;:
pubmed: 36418715
Gastroenterology. 2008 Aug;135(2):642-59
pubmed: 18602923
Clin Cancer Res. 2019 May 1;25(9):2887-2899
pubmed: 30705034
Tumour Biol. 2017 Mar;39(3):1010428317694551
pubmed: 28349818
Cell. 1998 Sep 18;94(6):703-14
pubmed: 9753318
Int J Biol Sci. 2022 Feb 21;18(5):1989-2002
pubmed: 35342355
Blood. 2022 Jun 23;139(25):3630-3646
pubmed: 35421216
J Biol Chem. 1998 Oct 30;273(44):29195-201
pubmed: 9786930
Cancers (Basel). 2021 Apr 03;13(7):
pubmed: 33916844
Cell Rep. 2021 Jul 27;36(4):109443
pubmed: 34320363
Cancers (Basel). 2022 Nov 30;14(23):
pubmed: 36497403
Anticancer Drugs. 2022 Oct 1;33(9):803-814
pubmed: 35946507
Mol Cancer. 2011 May 30;10:67
pubmed: 21624123
BMC Cancer. 2021 Apr 23;21(1):453
pubmed: 33892661
Cancer Res. 2020 Sep 1;80(17):3466-3479
pubmed: 32641411
Cell Rep. 2022 Dec 27;41(13):111878
pubmed: 36577366
Commun Biol. 2022 Oct 7;5(1):1068
pubmed: 36207615
Oncogene. 2010 Feb 4;29(5):674-86
pubmed: 19901970
Exp Cell Res. 2005 Jul 1;307(1):231-46
pubmed: 15922743
J Exp Clin Cancer Res. 2023 Apr 28;42(1):105
pubmed: 37106379
Food Chem Toxicol. 2021 Jan;147:111912
pubmed: 33290806
Oncogene. 2022 May;41(21):2945-2957
pubmed: 35437307
J Immunother Cancer. 2021 Feb;9(2):
pubmed: 33589523
Cell Death Dis. 2022 Jul 28;13(7):656
pubmed: 35902557
Cell Death Differ. 2020 Jun;27(6):1795-1806
pubmed: 31767934
Front Pharmacol. 2021 Dec 24;12:778781
pubmed: 35002714
Front Oncol. 2021 Mar 08;11:642030
pubmed: 33763375
J Clin Invest. 2022 Mar 1;132(5):
pubmed: 35085106
Onco Targets Ther. 2020 Mar 06;13:1993-2006
pubmed: 32184631
J Cancer. 2020 Sep 9;11(21):6402-6412
pubmed: 33033523
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3873-3882
pubmed: 30651315
J Cancer. 2021 Jan 16;12(6):1678-1686
pubmed: 33613755
Nat Commun. 2021 Aug 11;12(1):4853
pubmed: 34381046
J Oncol. 2022 Apr 26;2022:7823433
pubmed: 35518787
Eur Rev Med Pharmacol Sci. 2019 Nov;23(21):9436-9444
pubmed: 31773690
Am J Physiol Gastrointest Liver Physiol. 2000 Apr;278(4):G513-21
pubmed: 10762604
Signal Transduct Target Ther. 2023 Mar 24;8(1):120
pubmed: 36959211
Clin Transl Med. 2021 Jul;11(7):e410
pubmed: 34323416
J Biol Chem. 2020 Oct 2;295(40):13798-13811
pubmed: 32737199
J Clin Invest. 2008 Aug;118(8):2722-32
pubmed: 18618014
Int J Cancer. 2021 Jun 15;148(12):3060-3070
pubmed: 33521930
Hepatology. 2020 Sep;72(3):997-1012
pubmed: 31903610
Science. 1996 Jan 19;271(5247):350-3
pubmed: 8553070
Mol Carcinog. 2021 Dec;60(12):859-873
pubmed: 34551139
Mol Cell. 1999 Oct;4(4):499-509
pubmed: 10549282
iScience. 2020 Sep 03;23(9):101470
pubmed: 32888405
Clin Cancer Res. 2020 Jun 15;26(12):3058-3070
pubmed: 32139402
Cell. 2008 Jul 25;134(2):215-30
pubmed: 18662538
J Nutr Biochem. 2022 Sep;107:109039
pubmed: 35533902
Sci Rep. 2020 Nov 5;10(1):19214
pubmed: 33154524
Oncogene. 2021 Oct;40(41):6034-6048
pubmed: 34453124
Cancers (Basel). 2022 Oct 12;14(20):
pubmed: 36291778
Oncogene. 2020 Apr;39(14):2890-2904
pubmed: 32029901
Cancer Lett. 2021 May 28;506:128-141
pubmed: 33705863
Int J Mol Sci. 2020 Sep 05;21(18):
pubmed: 32899503
Nature. 1997 Jul 3;388(6637):82-7
pubmed: 9214507
World J Gastrointest Oncol. 2022 Nov 15;14(11):2157-2169
pubmed: 36438710
Aging (Albany NY). 2020 Nov 16;12(22):22759-22775
pubmed: 33202380
Cell Death Discov. 2021 Sep 7;7(1):234
pubmed: 34489426
Exp Mol Pathol. 2020 Oct;116:104489
pubmed: 32622014
Int J Biol Sci. 2020 Mar 12;16(9):1648-1657
pubmed: 32226309
J Exp Clin Cancer Res. 2022 Feb 22;41(1):73
pubmed: 35193647
Nature. 1994 Aug 4;370(6488):341-7
pubmed: 8047140
Cancer Sci. 2022 Apr;113(4):1250-1263
pubmed: 35048477
Int J Oncol. 2019 Jan;54(1):306-314
pubmed: 30365047
Lab Invest. 2021 Apr;101(4):463-476
pubmed: 33303972
Front Pharmacol. 2020 Aug 26;11:1324
pubmed: 32982740
Cancer Res. 2020 Jul 1;80(13):2804-2817
pubmed: 32376602
J Invest Dermatol. 2022 Aug;142(8):2228-2237.e4
pubmed: 35131256
Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2208927120
pubmed: 36626550
Genes Dev. 1999 Sep 1;13(17):2196-206
pubmed: 10485843
Oncogene. 2021 Jan;40(1):68-84
pubmed: 33051597
Cancer Res. 2022 Dec 16;82(24):4604-4623
pubmed: 36219392
Cancers (Basel). 2022 Mar 25;14(7):
pubmed: 35406446
Int J Biol Sci. 2020 Jan 30;16(6):1010-1022
pubmed: 32140069
Pancreas. 2009 Jul;38(5):551-7
pubmed: 19276868
Genes Dev. 2006 Nov 15;20(22):3130-46
pubmed: 17114584
Am J Pathol. 1998 Jul;153(1):287-94
pubmed: 9665490
Genetics. 1995 Mar;139(3):1347-58
pubmed: 7768443
Cancer Sci. 2020 Jan;111(1):59-71
pubmed: 31729097
Int J Pharm. 2022 Jul 25;623:121953
pubmed: 35753535
Ann Surg Oncol. 2009 Apr;16(4):826-35
pubmed: 19165547
Cancer Res. 2020 Mar 15;80(6):1304-1315
pubmed: 31941699
J Med Virol. 2020 Jan;92(1):96-106
pubmed: 31469179
Adv Sci (Weinh). 2022 Jan;9(1):e2101235
pubmed: 34791825
Gut. 2006 Jun;55(6):764-74
pubmed: 16368780
Gut. 2020 May;69(5):888-900
pubmed: 31611300
Clin Cancer Res. 2019 Mar 15;25(6):1948-1956
pubmed: 30587545
Bioengineered. 2021 Dec;12(1):225-239
pubmed: 33371778
Int J Mol Sci. 2020 Oct 07;21(19):
pubmed: 33036415
Signal Transduct Target Ther. 2021 Nov 17;6(1):395
pubmed: 34785655
J Exp Clin Cancer Res. 2020 Aug 4;39(1):150
pubmed: 32746934
Genes Cells. 2004 Feb;9(2):143-51
pubmed: 15009097
Nat Commun. 2023 Mar 31;14(1):1794
pubmed: 37002229
Protein Cell. 2021 Feb;12(2):128-144
pubmed: 32737864
J Cell Biochem. 2019 Jun;120(6):10796-10811
pubmed: 30701575
Breast Cancer Res Treat. 2021 Oct;189(3):607-619
pubmed: 34370213
Front Oncol. 2020 Oct 02;10:575358
pubmed: 33134174
Cell Death Dis. 2021 Sep 27;12(10):880
pubmed: 34580281
Cold Spring Harb Perspect Biol. 2016 May 02;8(5):
pubmed: 27141051
J Oncol. 2022 Apr 13;2022:3037348
pubmed: 35466322
Front Cell Dev Biol. 2021 Nov 29;9:738189
pubmed: 34912799
Environ Sci Pollut Res Int. 2023 May;30(24):65237-65249
pubmed: 37079240
Cancer Res. 2022 Jun 15;82(12):2239-2253
pubmed: 35395674
Annu Rev Biochem. 1998;67:753-91
pubmed: 9759503
Autophagy. 2020 Mar;16(3):486-500
pubmed: 31177911
Cancer Gene Ther. 2019 May;26(5-6):119-127
pubmed: 30177817
Mol Oncol. 2023 Feb;17(2):344-364
pubmed: 36550779
Hepatology. 2008 Oct;48(4):1128-37
pubmed: 18704924
J Gene Med. 2020 Jun;22(6):e3162
pubmed: 31951299
EMBO J. 2021 Apr 1;40(7):e106151
pubmed: 33616251
Dig Dis Sci. 2021 Jun;66(6):1862-1874
pubmed: 32705438
Mol Ther Nucleic Acids. 2019 Dec 6;18:851-862
pubmed: 31739210
Adv Sci (Weinh). 2022 Jan;9(3):e2105793
pubmed: 35075800
Cell Death Differ. 2021 Jan;28(1):219-232
pubmed: 32737443
Front Oncol. 2021 May 07;11:649778
pubmed: 34026626
Cell Death Dis. 2020 Jul 24;11(7):576
pubmed: 32709857
Onco Targets Ther. 2021 Feb 03;14:751-761
pubmed: 33568915
Cancer Res. 2000 Apr 1;60(7):2002-6
pubmed: 10766191
Bioengineered. 2022 Apr;13(4):8064-8075
pubmed: 35291909
Gastrointest Endosc. 2008 Mar;67(3):394-8
pubmed: 18045592
Cell. 1996 Oct 18;87(2):173
pubmed: 8861901
Oncol Rep. 2020 Aug;44(2):599-610
pubmed: 32627026
Genes Dev. 1998 Jul 15;12(14):2114-9
pubmed: 9679056
FASEB J. 2022 May;36(5):e22283
pubmed: 35344216
Sci Adv. 2019 Oct 23;5(10):eaaw3113
pubmed: 31681835
Cancers (Basel). 2021 Oct 05;13(19):
pubmed: 34638474