Cryopreserved Platelets in a Non-Toxic DMSO-Free Solution Maintain Hemostatic Function In Vitro.

Dimethyl Sulfoxide / pharmacology Blood Platelets Cryopreservation Cryoprotective Agents / pharmacology Saline Solution Hemostatics
activation cryopreservation dimethyl sulfoxide (DMSO, Me2SO) microparticles platelets transfusion

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
23 Aug 2023
Historique:
received: 12 07 2023
revised: 18 08 2023
accepted: 21 08 2023
medline: 11 9 2023
pubmed: 9 9 2023
entrez: 9 9 2023
Statut: epublish

Résumé

Dimethyl sulfoxide (DMSO) is regularly used as a cryoprotectant agent for the cryopreservation of platelets. However, DMSO is considered toxic. We therefore hypothesized that saline could be used as a non-toxic medium for the cryopreservation of platelets. Double-dose buffy coat platelets (

Identifiants

DOI: 10.3390/ijms241713097 PMID: 37685902 PMC: PMC10488190
pubmed: 37685902
pii: ijms241713097
doi: 10.3390/ijms241713097
pmc: PMC10488190
pii:
doi:

Substances chimiques

Dimethyl Sulfoxide YOW8V9698H
Cryoprotective Agents 0
Saline Solution 0
Hemostatics 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : by ALF grant (no. 510751) from the region of Stockholm and European Blood Alliance (EBA) research grant
ID : 510751

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Auteurs

Kristina Ehn (K)

Department of Clinical Immunology and Transfusion Medicine (KITM), Karolinska University Hospital, 141 86 Stockholm, Sweden.
Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 141 52 Huddinge, Sweden.

Agneta Wikman (A)

Department of Clinical Immunology and Transfusion Medicine (KITM), Karolinska University Hospital, 141 86 Stockholm, Sweden.
Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 141 52 Huddinge, Sweden.

Michael Uhlin (M)

Department of Clinical Immunology and Transfusion Medicine (KITM), Karolinska University Hospital, 141 86 Stockholm, Sweden.
Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 141 52 Huddinge, Sweden.
ORCID: 0000-0002-2177-6727

Per Sandgren (P)

Department of Clinical Immunology and Transfusion Medicine (KITM), Karolinska University Hospital, 141 86 Stockholm, Sweden.
Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 141 52 Huddinge, Sweden.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfoxydes › Diméthylsulfoxyde › Cryopreserved Platelets in a Non-Toxic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Plaquettes › Cryopreserved Platelets in a Non-Toxic...
questionsmedicales.fr › Techniques d'investigation › Conservation biologique › Cryoconservation › Cryopreserved Platelets in a Non-Toxic...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Cryoprotecteurs › Cryopreserved Platelets in a Non-Toxic...
questionsmedicales.fr › Préparations pharmaceutiques › Solutions › Solution isotonique › Cristalloïdes › Solution physiologique salée › Cryopreserved Platelets in a Non-Toxic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Coagulants › Hémostatiques › Cryopreserved Platelets in a Non-Toxic...