A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial.
3-deoxyglucosone
Citrus × sinensis
Punica × granatum
glyoxal
hesperidin
methylglyoxal
punicalagin
α-dicarbonyls
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Aug 2023
24 Aug 2023
Historique:
received:
29
07
2023
revised:
18
08
2023
accepted:
23
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Reactive α-dicarbonyls (α-DCs), such as methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), are potent precursors in the formation of advanced glycation end products (AGEs). In particular, MGO and MGO-derived AGEs are thought to be involved in the development of vascular complications in diabetes. Experimental studies showed that citrus and pomegranate polyphenols can scavenge α-DCs. Therefore, the aim of this study was to evaluate the effect of a citrus and pomegranate complex (CPC) on the α-DCs plasma levels in a double-blind, placebo-controlled cross-over trial, where thirty-six elderly subjects were enrolled. They received either 500 mg of
Identifiants
pubmed: 37685975
pii: ijms241713168
doi: 10.3390/ijms241713168
pmc: PMC10488144
pii:
doi:
Substances chimiques
Capsules
0
Glycation End Products, Advanced
0
Magnesium Oxide
3A3U0GI71G
Pyruvaldehyde
722KLD7415
Banques de données
ClinicalTrials.gov
['NCT03781999']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
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