Strategies for Engineering of Extracellular Vesicles.
EVs functionalization
active loading
click chemistry
drug delivery
electroporation
extracellular vesicles
extrusion
freeze-thawing
glycan modification
peptides
permeabilization
surface modification
ultrasound
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Aug 2023
26 Aug 2023
Historique:
received:
03
07
2023
revised:
14
08
2023
accepted:
17
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Extracellular vesicles (EVs) are membrane vesicles released by cells into the extracellular space. EVs mediate cell-to-cell communication through local and systemic transportation of biomolecules such as DNA, RNA, transcription factors, cytokines, chemokines, enzymes, lipids, and organelles within the human body. EVs gained a particular interest from cancer biology scientists because of their role in the modulation of the tumor microenvironment through delivering bioactive molecules. In this respect, EVs represent an attractive therapeutic target and a means for drug delivery. The advantages of EVs include their biocompatibility, small size, and low immunogenicity. However, there are several limitations that restrict the widespread use of EVs in therapy, namely, their low specificity and payload capacity. Thus, in order to enhance the therapeutic efficacy and delivery specificity, the surface and composition of extracellular vesicles should be modified accordingly. In this review, we describe various approaches to engineering EVs, and further discuss their advantages and disadvantages to promote the application of EVs in clinical practice.
Identifiants
pubmed: 37686050
pii: ijms241713247
doi: 10.3390/ijms241713247
pmc: PMC10488046
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Government Program "Recruitment of the Leading Scientists into the Russian Institu-tions of Higher Education"
ID : 075-15-2021-600
Références
Biomaterials. 2020 Jun;243:119942
pubmed: 32179302
Semin Cancer Biol. 2021 Sep;74:62-78
pubmed: 33609665
Cell Death Discov. 2018 Nov 13;4:103
pubmed: 30455989
Cytotechnology. 2016 Oct;68(5):2125-38
pubmed: 26856590
Adv Healthc Mater. 2021 Nov;10(22):e2101298
pubmed: 34569179
Front Immunol. 2020 Jun 03;11:943
pubmed: 32582146
PLoS One. 2015 Nov 03;10(11):e0141860
pubmed: 26529317
Cell Death Dis. 2021 Jan 4;12(1):17
pubmed: 33414456
J Hepatol. 2020 Dec;73(6):1507-1525
pubmed: 32682050
Cell Cycle. 2018;17(15):1917-1930
pubmed: 30109812
J Extracell Vesicles. 2019 Aug 9;8(1):1648995
pubmed: 31489145
Bioconjug Chem. 2014 Oct 15;25(10):1777-84
pubmed: 25220352
J Extracell Vesicles. 2015 Feb 09;4:26238
pubmed: 25669322
Biomaterials. 2018 Sep;178:302-316
pubmed: 29982104
Nano Lett. 2018 Aug 8;18(8):4965-4975
pubmed: 29995418
Cold Spring Harb Protoc. 2019 Jul 1;2019(7):
pubmed: 31262965
Bioconjug Chem. 2009 Dec;20(12):2199-213
pubmed: 19719118
Theranostics. 2017 Mar 16;7(5):1333-1345
pubmed: 28435469
Adv Protein Chem Struct Biol. 2015;98:1-55
pubmed: 25819275
J Extracell Vesicles. 2021 Feb;10(4):e12057
pubmed: 33643546
Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C29-C39
pubmed: 31693397
Cells. 2022 Jun 15;11(12):
pubmed: 35741061
Lab Chip. 2014 Apr 7;14(7):1261-9
pubmed: 24493004
J Control Release. 2015 Jun 10;207:18-30
pubmed: 25836593
Cancer Sci. 2017 Sep;108(9):1803-1810
pubmed: 28667694
AAPS J. 2018 Mar 15;20(3):50
pubmed: 29546642
Cancer Res. 2006 May 1;66(9):4795-801
pubmed: 16651434
J Biol Chem. 2015 Mar 27;290(13):8166-72
pubmed: 25657008
Nano Lett. 2019 Jan 9;19(1):19-28
pubmed: 30517011
Phytochem Rev. 2010 Sep;9(3):425-474
pubmed: 20835386
Sci Rep. 2016 Feb 25;6:21933
pubmed: 26911358
Angew Chem Int Ed Engl. 2021 Mar 29;60(14):7582-7586
pubmed: 33382182
Mol Ther Methods Clin Dev. 2019 Jan 09;13:133-144
pubmed: 30788382
Scand J Immunol. 2015 Jan;81(1):2-10
pubmed: 25359529
Infect Immun. 2020 Nov 16;88(12):
pubmed: 32989035
ACS Nano. 2017 Aug 22;11(8):7736-7746
pubmed: 28727410
Nat Biotechnol. 2011 Apr;29(4):341-5
pubmed: 21423189
Front Immunol. 2019 Nov 15;10:2663
pubmed: 31849929
Biomol Concepts. 2016 Jun 1;7(3):179-87
pubmed: 27159920
Trends Neurosci. 2019 May;42(5):361-372
pubmed: 30926143
Oncotarget. 2013 Oct;4(10):1556-71
pubmed: 24298606
Nat Commun. 2020 Apr 14;11(1):1790
pubmed: 32286296
Protoplasma. 2020 Jan;257(1):3-12
pubmed: 31468195
Nat Commun. 2012;3:1282
pubmed: 23250412
Bioact Mater. 2022 Aug 11;25:500-526
pubmed: 37056271
Front Chem. 2022 Feb 24;10:844124
pubmed: 35281563
Cells. 2019 Jul 15;8(7):
pubmed: 31311206
Nat Biomed Eng. 2020 Jan;4(1):69-83
pubmed: 31844155
J Nanobiotechnology. 2020 Aug 14;18(1):113
pubmed: 32799868
Chest. 2018 Jan;153(1):210-216
pubmed: 28684288
J Extracell Vesicles. 2021 Nov;10(13):e12163
pubmed: 34719860
Acta Biomater. 2021 Oct 15;134:13-31
pubmed: 34284151
Adv Drug Deliv Rev. 2020;159:332-343
pubmed: 32305351
Pharmacol Res. 2016 Sep;111:487-500
pubmed: 27394168
Nanoscale. 2019 Jan 23;11(4):1531-1537
pubmed: 30623961
Int J Mol Sci. 2022 Sep 10;23(18):
pubmed: 36142433
Front Microbiol. 2022 Feb 23;13:835058
pubmed: 35283837
Mol Ther. 2010 Sep;18(9):1606-14
pubmed: 20571541
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 Jan;15(1):e1835
pubmed: 35898167
Bioconjug Chem. 2018 Mar 21;29(3):686-701
pubmed: 29287474
Cancers (Basel). 2019 Aug 28;11(9):
pubmed: 31466401
Theranostics. 2021 Mar 5;11(11):5107-5126
pubmed: 33859737
Cell Mol Life Sci. 2018 Jan;75(2):193-208
pubmed: 28733901
Nanomedicine. 2016 Apr;12(3):655-664
pubmed: 26586551
J Control Release. 2019 Jul 28;306:108-120
pubmed: 31175896
ACS Med Chem Lett. 2015 Jul 06;6(8):856-60
pubmed: 26288684
J Extracell Vesicles. 2023 Feb;12(2):e12305
pubmed: 36775986
Biomicrofluidics. 2020 Jan 27;14(1):011501
pubmed: 32002105
Sci Adv. 2020 May 01;6(18):eaaz0952
pubmed: 32494669
Cells. 2020 Jul 02;9(7):
pubmed: 32630649
Nanomedicine (Lond). 2016 Jul;11(13):1745-56
pubmed: 27348448
Front Microbiol. 2017 Jun 09;8:1053
pubmed: 28649237
Int J Nanomedicine. 2018 Jan 30;13:585-599
pubmed: 29430178
Cells. 2020 Nov 15;9(11):
pubmed: 33203181
Acta Naturae. 2021 Jul-Sep;13(3):114-121
pubmed: 34707904
Adv Drug Deliv Rev. 2010 Aug 30;62(11):1005-22
pubmed: 20851156
J Control Release. 2015 Dec 10;219:396-405
pubmed: 26241750
Biomaterials. 2014 Feb;35(7):2383-90
pubmed: 24345736
Cancer Res. 2018 Feb 1;78(3):798-808
pubmed: 29217761
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Front Cell Dev Biol. 2021 Apr 07;9:653322
pubmed: 33898449
J Biomech Eng. 2009 Jul;131(7):074005
pubmed: 19655996
Magn Reson Med. 2015 Jul;74(1):266-271
pubmed: 25052384
Angew Chem Int Ed Engl. 2021 Aug 9;60(33):18111-18115
pubmed: 34043264
ACS Appl Nano Mater. 2020 Jul 24;3(7):7211-7222
pubmed: 34568770
Anal Chem. 2019 Feb 5;91(3):2425-2430
pubmed: 30620179
J Control Release. 2015 May 10;205:35-44
pubmed: 25483424
J Extracell Vesicles. 2018 Mar 04;7(1):1442985
pubmed: 29535851
Biomaterials. 2021 Feb;269:120467
pubmed: 33189359
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2284-9
pubmed: 12606722
J Extracell Vesicles. 2016 Mar 14;5:31053
pubmed: 26979463
J Control Release. 2014 Oct 28;192:262-70
pubmed: 25084218
Small. 2019 Nov;15(47):e1903761
pubmed: 31614072
Biochim Biophys Acta Gen Subj. 2018 May;1862(5):1091-1100
pubmed: 29410228
Stem Cells Int. 2019 Jun 2;2019:2831756
pubmed: 31281371
Sci Transl Med. 2018 Jun 6;10(444):
pubmed: 29875202
Lab Chip. 2021 Feb 7;21(3):597-607
pubmed: 33367429
Int J Mol Sci. 2021 Jul 05;22(13):
pubmed: 34281276
Sci Transl Med. 2019 May 15;11(492):
pubmed: 31092696
Oncotarget. 2016 Jan 26;7(4):4584-97
pubmed: 26683709
Anal Chem. 2020 Dec 1;92(23):15497-15505
pubmed: 33175504
Biomed Res Int. 2018 Jan 30;2018:8545347
pubmed: 29662902
Annu Rev Immunol. 2018 Apr 26;36:435-459
pubmed: 29400984
Sci Transl Med. 2019 Jan 9;11(474):
pubmed: 30626714
PLoS One. 2013 Apr 19;8(4):e61852
pubmed: 23620794
Front Cell Dev Biol. 2021 Apr 06;9:659783
pubmed: 33889576
Mol Ther. 2013 Jan;21(1):185-91
pubmed: 23032975
Biochem Biophys Res Commun. 2018 May 23;499(4):803-808
pubmed: 29621543
Pharm Res. 2015 Jun;32(6):2003-14
pubmed: 25609010
Biomaterials. 2018 Jan;150:137-149
pubmed: 29040874
ACS Nano. 2017 Jan 24;11(1):69-83
pubmed: 28068069
Life Sci. 2014 Jun 27;107(1-2):1-7
pubmed: 24780320