Metabolic Imbalances and Bone Remodeling Agents in Adolescent Idiopathic Scoliosis: A Study in Postmenarcheal Girls.
FGF23
Klotho
PINP
deformity
phosphate–calcium metabolism
scoliosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Aug 2023
27 Aug 2023
Historique:
received:
02
08
2023
revised:
21
08
2023
accepted:
25
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
The causes and mechanisms underlying adolescent idiopathic scoliosis (AIS) remain unclear, and the available information regarding metabolic imbalances in AIS is still insufficient. This investigation aimed to evaluate the concentrations of specific bone remodeling-related agents in postmenarcheal girls diagnosed with AIS. The study encompassed thirty-six scoliosis patients and eighteen age-matched healthy individuals assigned to the control group. The patients underwent clinical and radiological examinations to assess the degree of the spinal deformity, type of curvature, and skeletal maturity. Blood and urine samples were collected from all participants and serological markers were measured using an enzyme-linked immunosorbent assay. Our study results demonstrated that the balance of phosphate-calcium and parathormone levels seems normal in individuals with AIS. Furthermore, no statistically significant differences were observed in the content of Klotho protein, osteocalcin, osteoprotegerin, C-terminal telopeptide of type I collagen (CTX), sclerostin, and alkaline phosphatase. Nevertheless, the serum levels of vitamin D (25-OH-D) were lowered, while N-terminal propeptide of type I procollagen (PINP), and fibroblast growth factor-23 (FGF23) were increased in the AIS group, with
Identifiants
pubmed: 37686090
pii: ijms241713286
doi: 10.3390/ijms241713286
pmc: PMC10487495
pii:
doi:
Substances chimiques
Procollagen Type I
0
Alkaline Phosphatase
EC 3.1.3.1
Collagen Type I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
World J Orthop. 2021 Aug 18;12(8):584-603
pubmed: 34485105
J Clin Med. 2022 Dec 22;12(1):
pubmed: 36614877
Int Orthop. 2015 Jun;39(6):1227-36
pubmed: 25804208
Nutrients. 2013 Sep 13;5(9):3605-16
pubmed: 24067388
Bone. 2019 Mar;120:364-370
pubmed: 30481617
J Orthop Surg Res. 2020 Oct 30;15(1):502
pubmed: 33121521
BMC Musculoskelet Disord. 2023 Jan 20;24(1):48
pubmed: 36670417
Acta Orthop Traumatol Turc. 2019 Nov;53(6):468-473
pubmed: 31628002
Children (Basel). 2022 Oct 25;9(11):
pubmed: 36360347
J Med Life. 2020 Apr-Jun;13(2):260-264
pubmed: 32728404
Arch Orthop Trauma Surg. 2017 Oct;137(10):1327-1333
pubmed: 28710669
Int J Mol Sci. 2016 Jul 20;17(7):
pubmed: 27447624
Int J Environ Res Public Health. 2022 Mar 16;19(6):
pubmed: 35329213
FASEB J. 2021 Sep;35(9):e21839
pubmed: 34387890
J Clin Med. 2022 Dec 20;12(1):
pubmed: 36614806
Mediators Inflamm. 2021 May 25;2021:5537811
pubmed: 34121924
J Orthop Surg Res. 2018 Sep 4;13(1):223
pubmed: 30180899
Spine (Phila Pa 1976). 2021 May 15;46(10):E594-E601
pubmed: 33290378
Nat Rev Dis Primers. 2015 Sep 24;1:15030
pubmed: 27188385
Chin Med J (Engl). 2023 Jun 20;136(12):1468-1477
pubmed: 37192015
FASEB J. 2019 Dec 1;33(12):13882-13892
pubmed: 31626573
Int J Mol Sci. 2020 Oct 12;21(20):
pubmed: 33053789
Biomed Res Int. 2018 Jul 16;2018:9784083
pubmed: 30079352
Healthcare (Basel). 2022 Feb 20;10(2):
pubmed: 35207011
Clin Orthop Relat Res. 2012 Aug;470(8):2335-8
pubmed: 22538960
Bone. 2021 Feb;143:115655
pubmed: 32979537
Nutrients. 2016 Jan 28;8(2):71
pubmed: 26828519
Spine (Phila Pa 1976). 2016 Apr;41(8):693-7
pubmed: 27064335
J Clin Med. 2021 Mar 18;10(6):
pubmed: 33803785
Nat Rev Endocrinol. 2022 Jun;18(6):366-384
pubmed: 35484227
J Clin Med. 2022 May 09;11(9):
pubmed: 35566795
Adv Clin Exp Med. 2019 Aug;28(8):1073-1077
pubmed: 31237121
Children (Basel). 2022 May 21;9(5):
pubmed: 35626935
BMC Musculoskelet Disord. 2019 May 24;20(1):247
pubmed: 31122237
Ortop Traumatol Rehabil. 2019 Aug 31;21(4):271-278
pubmed: 32015205
J Bone Miner Res. 2018 Sep;33(9):1641-1648
pubmed: 29669167
Biomed Res Int. 2016;2016:8460291
pubmed: 28042574
Proteomics Clin Appl. 2021 Jul;15(4):e2100002
pubmed: 33864425
Kidney Int. 2015 Mar;87(3):499-501
pubmed: 25723633
Sci Rep. 2016 Mar 01;6:22274
pubmed: 26928931
Gene. 2020 Sep 5;754:144855
pubmed: 32522695
Osteoporos Int. 2016 Aug;27(8):2477-88
pubmed: 27010646
Eur Spine J. 2009 Dec;18(12):1936-40
pubmed: 19705167
Osteoporos Int. 2005 Dec;16(12):1924-32
pubmed: 16163440
J Pediatr Orthop B. 2017 Jan;26(1):48-52
pubmed: 27089048
Toxins (Basel). 2020 Mar 17;12(3):
pubmed: 32192220
Ortop Traumatol Rehabil. 2009 Sep-Oct;11(5):438-47
pubmed: 19920286
J Clin Med. 2021 Nov 14;10(22):
pubmed: 34830568
J Clin Invest. 2008 Dec;118(12):3820-8
pubmed: 19033649
Scoliosis. 2015 Mar 19;10:9
pubmed: 25949272
Ther Adv Musculoskelet Dis. 2014 Apr;6(2):48-57
pubmed: 24688605
Healthcare (Basel). 2021 Oct 14;9(10):
pubmed: 34683052
Children (Basel). 2022 Oct 22;9(11):
pubmed: 36360336