Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants.
end-stage liver disease
genetic polymorphisms
metabolic dysfunction-associated steatohepatitis
metabolic-dysfunction-associated steatotic liver disease
nonalcoholic steatohepatitis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Aug 2023
29 Aug 2023
Historique:
received:
28
06
2023
revised:
15
08
2023
accepted:
25
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Metabolic-dysfunction-associated steatotic liver disease (MASLD), which affects 30 million people in the US and is anticipated to reach over 100 million by 2030, places a significant financial strain on the healthcare system. There is presently no FDA-approved treatment for MASLD despite its public health significance and financial burden. Understanding the connection between point mutations, liver enzymes, and MASLD is important for comprehending drug toxicity in healthy or diseased individuals. Multiple genetic variations have been linked to MASLD susceptibility through genome-wide association studies (GWAS), either increasing MASLD risk or protecting against it, such as
Identifiants
pubmed: 37686209
pii: ijms241713406
doi: 10.3390/ijms241713406
pmc: PMC10487897
pii:
doi:
Substances chimiques
Cytochrome P-450 CYP2C8
EC 1.14.14.1
Cytochrome P-450 CYP2E1
EC 1.14.13.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : UH3 DK119973
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK120531
Pays : United States
Organisme : NIDDK NIH HHS
ID : UG3 DK119973
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099257
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117881
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR003289
Pays : United States
Organisme : NCATS NIH HHS
ID : UG3 TR003289
Pays : United States
Organisme : NCATS NIH HHS
ID : U01 TR002383
Pays : United States
Organisme : NIDDK NIH HHS
ID : P01 DK096990
Pays : United States
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