A Deep View of the Biological Property of Interleukin-33 and Its Dysfunction in the Gut.
IL-33
biological characteristics
gastrointestinal cancer
inflammatory bowel disease
nuclear IL-33
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Aug 2023
31 Aug 2023
Historique:
received:
31
07
2023
revised:
19
08
2023
accepted:
25
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Intestinal diseases have always posed a serious threat to human health, with inflammatory bowel disease (IBD) being one of them. IBD is an autoimmune disease characterized by chronic inflammation, including ulcerative colitis (UC) and Crohn's disease (CD). The "alarm" cytokine IL-33, which is intimately associated with Th2 immunity, is a highly potent inflammatory factor that is considered to have dual functions-operating as both a pro-inflammatory cytokine and a transcriptional regulator. IL-33 has been shown to play a crucial role in both the onset and development of IBD. Therefore, this review focuses on the pathogenesis of IBD, the major receptor cell types, and the activities of IL-33 in innate and adaptive immunity, as well as its underlying mechanisms and conflicting conclusions in IBD. We have also summarized different medicines targeted to IL-33-associated diseases. Furthermore, we have emphasized the role of IL-33 in gastrointestinal cancer and parasitic infections, giving novel prospective therapeutic utility in the future application of IL-33.
Identifiants
pubmed: 37686309
pii: ijms241713504
doi: 10.3390/ijms241713504
pmc: PMC10487440
pii:
doi:
Substances chimiques
Cytokines
0
Interleukin-33
0
IL33 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the National Natural Science Foundation of China
ID : 82174056
Références
Am J Pathol. 2003 Jul;163(1):69-79
pubmed: 12819012
Elife. 2020 May 18;9:
pubmed: 32420871
Br J Cancer. 2016 Jan 12;114(1):37-43
pubmed: 26679377
World J Gastroenterol. 2021 Oct 14;27(38):6489-6500
pubmed: 34720537
Chem Biol Interact. 2021 Jan 5;333:109315
pubmed: 33171134
Front Immunol. 2017 Apr 24;8:453
pubmed: 28484453
Cell Mol Immunol. 2017 Mar;14(3):285-292
pubmed: 26343805
Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2487-96
pubmed: 25918379
Nature. 2023 Mar;615(7950):151-157
pubmed: 36509106
J Physiol. 2018 Sep;596(17):3869-3882
pubmed: 29806140
Cell Mol Gastroenterol Hepatol. 2019;8(1):21-36
pubmed: 30831322
Int J Mol Sci. 2022 Aug 24;23(17):
pubmed: 36076997
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13463-8
pubmed: 19666510
Immunity. 2017 Oct 17;47(4):710-722.e6
pubmed: 29045902
Gut. 2013 Dec;62(12):1714-23
pubmed: 23172891
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):282-7
pubmed: 23248269
World J Gastroenterol. 2021 Nov 21;27(43):7402-7422
pubmed: 34887639
Nat Commun. 2021 May 5;12(1):2538
pubmed: 33953160
Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2116279119
pubmed: 35238669
JCI Insight. 2018 Jul 26;3(14):
pubmed: 30046004
Sci Rep. 2020 Feb 26;10(1):3479
pubmed: 32103032
Cell Rep. 2019 Nov 5;29(6):1469-1481.e9
pubmed: 31693889
Immunity. 2009 Jul 17;31(1):84-98
pubmed: 19559631
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7249-54
pubmed: 25941360
Nat Commun. 2018 Aug 14;9(1):3244
pubmed: 30108214
Front Immunol. 2021 Jul 26;12:688647
pubmed: 34381446
World J Gastroenterol. 2011 May 7;17(17):2181-90
pubmed: 21633527
Immunity. 2017 Oct 17;47(4):739-751.e5
pubmed: 29045903
Immunity. 2017 May 16;46(5):863-874.e4
pubmed: 28514691
Surg Clin North Am. 2017 Jun;97(3):627-639
pubmed: 28501251
Nat Immunol. 2021 Nov;22(11):1367-1374
pubmed: 34686862
Oncogene. 2022 Mar;41(11):1563-1575
pubmed: 35091681
Mayo Clin Proc. 2021 Oct;96(10):2694-2707
pubmed: 34538424
J Am Coll Cardiol. 2019 Oct 29;74(17):2193-2203
pubmed: 31648713
Front Immunol. 2022 Jan 20;12:758829
pubmed: 35126350
Biochem Biophys Res Commun. 2012 May 4;421(2):305-11
pubmed: 22708120
Immunity. 2009 Jul 17;31(1):5-7
pubmed: 19604486
Cancer Res. 2015 Sep 15;75(18):3760-70
pubmed: 26206557
Front Immunol. 2017 Apr 24;8:475
pubmed: 28484466
Front Immunol. 2022 May 30;13:867351
pubmed: 35707544
Mucosal Immunol. 2021 Jul;14(4):923-936
pubmed: 33654214
Sci Immunol. 2020 Nov 13;5(53):
pubmed: 33188058
Front Immunol. 2018 Oct 24;9:2432
pubmed: 30405626
Immunobiology. 2020 Mar;225(2):151886
pubmed: 31812341
Gastroenterology. 2021 Jan;160(2):524-537
pubmed: 33253681
Cancer Immunol Res. 2018 Apr;6(4):409-421
pubmed: 29463593
Immunity. 2020 Apr 14;52(4):635-649.e4
pubmed: 32240600
Front Immunol. 2019 Mar 20;10:522
pubmed: 30949175
Cell Death Discov. 2022 Apr 5;8(1):163
pubmed: 35383145
Nutrients. 2020 Jul 02;12(7):
pubmed: 32630805
Sci Signal. 2017 Dec 05;10(508):
pubmed: 29208683
J Allergy Clin Immunol. 2016 Sep;138(3):666-675
pubmed: 27476889
Mucosal Immunol. 2022 Jan;15(1):165-175
pubmed: 34400793
Mucosal Immunol. 2019 Jul;12(4):990-1003
pubmed: 31165767
J Exp Clin Cancer Res. 2018 Aug 17;37(1):196
pubmed: 30119635
J Immunol. 2011 Aug 15;187(4):1609-16
pubmed: 21734074
Nat Immunol. 2020 Jan;21(1):75-85
pubmed: 31844326
Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2705-13
pubmed: 27091974
Front Immunol. 2022 Sep 13;13:946643
pubmed: 36177009
Gastroenterology. 2022 Mar;162(3):715-730.e3
pubmed: 34757143
Nat Rev Microbiol. 2019 Aug;17(8):497-511
pubmed: 31249397
J Exp Med. 2016 Apr 4;213(4):569-83
pubmed: 26976630
Cell Death Dis. 2023 Mar 1;14(3):174
pubmed: 36859530
JCI Insight. 2020 May 7;5(9):
pubmed: 32376804
Immunity. 2012 Oct 19;37(4):634-48
pubmed: 23063333
Allergol Int. 2018 Sep;67S:S32-S37
pubmed: 29941231
Int J Mol Sci. 2020 Jan 19;21(2):
pubmed: 31963828
Immunity. 2022 Apr 12;55(4):623-638.e5
pubmed: 35385697
Int Immunopharmacol. 2022 Dec;113(Pt B):109466
pubmed: 36435061
Int Immunol. 2016 Jan;28(1):23-8
pubmed: 26232596
Int J Mol Sci. 2020 Feb 24;21(4):
pubmed: 32102434
Am J Pathol. 2008 Oct;173(4):1229-42
pubmed: 18787100
Inflamm Bowel Dis. 2015 Dec;21(12):2737-46
pubmed: 26313694
Gut. 2006 Feb;55(2):205-11
pubmed: 16188921
Int J Mol Sci. 2022 Jul 20;23(14):
pubmed: 35887337
Immunity. 2021 Jan 12;54(1):151-163.e6
pubmed: 33220232
Lancet. 2012 Nov 3;380(9853):1606-19
pubmed: 22914296
Oncotarget. 2017 Jun 7;8(31):51688-51702
pubmed: 28881679
J Clin Invest. 2021 Oct 1;131(19):
pubmed: 34343135
FEBS J. 2019 Feb;286(3):507-522
pubmed: 30576068
J Exp Med. 2016 Apr 4;213(4):555-67
pubmed: 26951334
Sci Rep. 2017 Apr 12;7(1):851
pubmed: 28404987
Cancer Res. 2014 Aug 15;74(16):4258-69
pubmed: 24906621
J Am Coll Cardiol. 2010 Jan 19;55(3):251-3
pubmed: 20117404
Front Immunol. 2021 Jul 15;12:669787
pubmed: 34335571
Immunity. 2015 Jun 16;42(6):1005-19
pubmed: 26084021
Mucosal Immunol. 2011 Sep;4(5):496-502
pubmed: 21613987
Pharmacol Ther. 2021 Sep;225:107847
pubmed: 33819560
Eur J Pharmacol. 2018 Jan 5;818:235-240
pubmed: 29107673
Mediators Inflamm. 2015;2015:913041
pubmed: 26161006
Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1673-8
pubmed: 22307629
Int J Mol Sci. 2015 Nov 24;16(11):27956-66
pubmed: 26610488
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):367-72
pubmed: 24344271
Mol Med. 2012 Jul 18;18:753-61
pubmed: 22426954
J Immunol. 2019 Jan 15;202(2):598-607
pubmed: 30530480
Am J Pathol. 2016 Apr;186(4):885-98
pubmed: 26908008
Sci Rep. 2016 Oct 03;6:34255
pubmed: 27694941
Int J Mol Med. 2011 Oct;28(4):573-8
pubmed: 21667014
J Clin Invest. 2021 Mar 1;131(5):
pubmed: 33444291
J Immunol Res. 2020 Dec 15;2020:8813558
pubmed: 33381606
Cell Rep. 2018 Mar 13;22(11):2937-2950
pubmed: 29539422
Sci Rep. 2021 May 5;11(1):9575
pubmed: 33953267
J Immunol. 2014 Oct 15;193(8):4010-20
pubmed: 25217167
Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10762-7
pubmed: 26243875
Immunol Rev. 2018 Jan;281(1):154-168
pubmed: 29247993
Eur J Heart Fail. 2012 Mar;14(3):268-77
pubmed: 22302661
Blood Adv. 2018 Sep 25;2(18):2282-2295
pubmed: 30213787
Immunity. 2017 Dec 19;47(6):1024-1036
pubmed: 29262347
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):8017-22
pubmed: 20385815
Int Immunol. 2008 Jun;20(6):791-800
pubmed: 18448455
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9362-E9370
pubmed: 30224451
Nat Rev Immunol. 2016 Nov;16(11):676-689
pubmed: 27640624
Nat Commun. 2017 Nov 23;8(1):1741
pubmed: 29170498
Front Immunol. 2018 Dec 20;9:3051
pubmed: 30619376
Nat Commun. 2019 Jun 21;10(1):2735
pubmed: 31227713
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18660-5
pubmed: 18003919
J Am Soc Nephrol. 2011 Nov;22(11):2057-67
pubmed: 21949094
J Immunol. 2009 Mar 1;182(5):2601-9
pubmed: 19234154
Mucosal Immunol. 2019 May;12(3):632-643
pubmed: 30742042
Front Immunol. 2020 Jun 30;11:1363
pubmed: 32695116
Eur Cytokine Netw. 2012 Oct-Dec;23(4):120-7
pubmed: 23306193
Nat Immunol. 2012 Jun 03;13(7):651-8
pubmed: 22660580
Front Cardiovasc Med. 2020 Jul 28;7:115
pubmed: 32850979
J Immunol Res. 2019 Dec 1;2019:7247238
pubmed: 31886308
Sci Rep. 2019 Dec 5;9(1):18423
pubmed: 31804564
J Clin Invest. 2019 Apr 1;129(4):1441-1451
pubmed: 30932910
Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):56-66
pubmed: 33033392
J Immunol. 2007 Aug 15;179(4):2551-5
pubmed: 17675517
Ann Hepatol. 2019 Mar - Apr;18(2):366-372
pubmed: 31053540
Semin Cancer Biol. 2020 Aug;64:51-60
pubmed: 31112753
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1588-1592
pubmed: 29429965
Nat Commun. 2021 Feb 5;12(1):836
pubmed: 33547321
J Neuroinflammation. 2020 Jun 6;17(1):174
pubmed: 32505187
J Cell Mol Med. 2018 Dec;22(12):6122-6133
pubmed: 30216659
EMBO J. 2021 Apr 1;40(7):e106151
pubmed: 33616251
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2646-2651
pubmed: 30696763
J Clin Invest. 2016 Dec 1;126(12):4469-4481
pubmed: 27775548
Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9021-6
pubmed: 19439663
Immunity. 2005 Nov;23(5):479-90
pubmed: 16286016
Cells. 2021 Dec 30;11(1):
pubmed: 35011670
Cell Host Microbe. 2014 Mar 12;15(3):382-392
pubmed: 24629344
J Biol Chem. 2014 Jan 3;289(1):237-50
pubmed: 24257755
Gut. 2004 May;53(5):685-93
pubmed: 15082587
Nature. 2014 Sep 25;513(7519):564-568
pubmed: 25043027
Immunology. 2013 Sep;140(1):70-7
pubmed: 23582173
Mayo Clin Proc. 2019 Jan;94(1):155-165
pubmed: 30611442
Nat Commun. 2015 Sep 14;6:8327
pubmed: 26365875
Cell Prolif. 2021 Jan;54(1):e12958
pubmed: 33174662