Mucins 3A and 3B Are Expressed in the Epithelium of Human Large Airway.
COPD
bronchoalveolar lavage
epithelium
immunohistochemistry
large airways
lung function
mRNA
microarray
mucin
smoking
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Aug 2023
31 Aug 2023
Historique:
received:
07
07
2023
revised:
25
08
2023
accepted:
29
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Aberrant mucus secretion is a hallmark of chronic obstructive pulmonary disease (COPD). Expression of the membrane-tethered mucins 3A and 3B (MUC3A, MUC3B) in human lung is largely unknown. In this observational cross-sectional study, we recruited subjects 45-65 years old from the general population of Stockholm, Sweden, during the years 2007-2011. Bronchial mucosal biopsies, bronchial brushings, and bronchoalveolar lavage fluid (BALF) were retrieved from COPD patients (n = 38), healthy never-smokers (n = 40), and smokers with normal lung function (n = 40). Protein expression of MUC3A and MUC3B in bronchial mucosal biopsies was assessed by immunohistochemical staining. In a subgroup of subjects (n = 28), MUC3A and MUC3B mRNAs were quantified in bronchial brushings using microarray. Non-parametric tests were used to perform correlation and group comparison analyses. A value of
Identifiants
pubmed: 37686350
pii: ijms241713546
doi: 10.3390/ijms241713546
pmc: PMC10487631
pii:
doi:
Substances chimiques
Mucins
0
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Jalmari and Rauha Ahokas Foundation
Organisme : Research Foundation of the Pulmonary Diseases
Organisme : a state subsidy of Oulu University Hospital
Organisme : Swedish Heart-Lung Foundation
Organisme : King Gustaf V's and Queen Victoria's Freemasons' Foundation
Organisme : Karolinska Institutet
Organisme : The Swedish Research Council
ID : 2018-00520
Organisme : Regional Agreement on Medical Training and Clinical Research (ALF) between Stockholm County Council and Karolinska Institutet
Organisme : ERS-EU RESPIRE2 MCF
ID : [7214]-2013
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