Effect of Repeated Bolus and Continuous Glucose Infusion on DNA Damage and Oxidative Stress Biomarkers in Healthy Male Volunteers.
DNA damage
ROS
antioxidants
bilirubin
comet assay
glucose
glucose variability
hyperglycemia
oxidative stress
protein carbonyls
type 2 diabetes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Sep 2023
02 Sep 2023
Historique:
received:
27
07
2023
revised:
30
08
2023
accepted:
31
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Glucose variability (GV), which describes fluctuations in blood glucose levels within the day, is a phenomenon that is increasingly becoming the target of scientific attention when it comes to increased risk of coronary heart disease. Effects of GV may contribute to the development of metabolic syndrome and type 2 diabetes. Hyperglycemia can lead to oxidative stress resulting in molecular damage due to accumulation of reactive oxygen species (ROS). To discover more about the immediate effects of GV, continuous vs. bolus intravenous glucose administration was applied to 10 healthy men aged 21-30 years over a time frame of 48 h. Whole blood and plasma were analyzed for DNA damage using a comet assay with 3 different treatments (lysis buffer, H
Identifiants
pubmed: 37686414
pii: ijms241713608
doi: 10.3390/ijms241713608
pmc: PMC10487933
pii:
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Hydrogen Peroxide
BBX060AN9V
Bilirubin
RFM9X3LJ49
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Sci Rep. 2015 Sep 04;5:13752
pubmed: 26337123
Diabetes Res Clin Pract. 2006 Sep;73(3):227-34
pubmed: 16624439
Mutagenesis. 2008 May;23(3):143-51
pubmed: 18283046
Free Radic Biol Med. 2018 Jun;121:69-77
pubmed: 29698742
Diabetes Res Clin Pract. 2014 Sep;105(3):356-63
pubmed: 25043705
Nutrients. 2021 Sep 30;13(10):
pubmed: 34684481
Mutat Res. 2004 Oct 4;554(1-2):297-304
pubmed: 15450427
Lancet. 2010 Jun 26;375(9733):2215-22
pubmed: 20609967
Mutat Res Rev Mutat Res. 2020 Jan - Mar;783:108288
pubmed: 32192646
Chronobiol Int. 2002 Mar;19(2):423-39
pubmed: 12025934
Biochim Biophys Acta. 2012 May;1822(5):729-36
pubmed: 22186191
Clin Interv Aging. 2018 Apr 26;13:757-772
pubmed: 29731617
Mutagenesis. 2012 Nov;27(6):731-5
pubmed: 22874647
J Clin Invest. 1986 Jan;77(1):322-5
pubmed: 3944257
Life Sci Alliance. 2021 Aug 23;4(10):
pubmed: 34426491
Trends Endocrinol Metab. 2007 Jan-Feb;18(1):4-11
pubmed: 17140805
Anal Biochem. 1996 Jul 15;239(1):70-6
pubmed: 8660627
PLoS One. 2022 Dec 27;17(12):e0279308
pubmed: 36574434
Nature. 2000 Apr 13;404(6779):787-90
pubmed: 10783895
Mutat Res. 2009 Mar 31;674(1-2):101-8
pubmed: 19041417
Antioxid Redox Signal. 2013 Jul 10;19(2):192-208
pubmed: 23198849
Methods Enzymol. 1990;186:464-78
pubmed: 1978225
Diabetes Ther. 2019 Jun;10(3):853-863
pubmed: 31037553
Nature. 2001 Dec 13;414(6865):813-20
pubmed: 11742414
Clin Endocrinol (Oxf). 2012 Jun;76(6):810-5
pubmed: 21854404
Mutat Res. 2001 Sep 1;480-481:371-8
pubmed: 11506829
Lipids. 2010 Apr;45(4):321-7
pubmed: 20224977
JAMA. 2000 May 3;283(17):2240-1
pubmed: 10807381
Can J Diabetes. 2015 Feb;39(1):44-9
pubmed: 25065473
J Clin Invest. 2001 Nov;108(9):1341-8
pubmed: 11696579
Chronobiol Int. 2003 Nov;20(6):921-62
pubmed: 14680136
Clin Chim Acta. 2003 Mar;329(1-2):23-38
pubmed: 12589963
Circ Res. 2010 Oct 29;107(9):1058-70
pubmed: 21030723
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12222-6
pubmed: 11050244
Curr Pharm Des. 2013;19(32):5695-703
pubmed: 23448484
J Diabetes Complications. 2013 Nov-Dec;27(6):548-52
pubmed: 24012111
Diabetes Metab J. 2015 Aug;39(4):273-82
pubmed: 26301188
PLoS One. 2016 Sep 06;11(9):e0162082
pubmed: 27598300
Clin Sci (Lond). 2015 Jul;129(1):1-25
pubmed: 25881719