Locally Advanced Adrenocortical Carcinoma in Children and Adolescents-Enigmatic and Challenging Cases.
adrenocortical carcinoma
children and adolescents
locally advanced disease
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
28 Aug 2023
28 Aug 2023
Historique:
received:
31
07
2023
revised:
21
08
2023
accepted:
25
08
2023
medline:
9
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Locally advanced tumors account for approximately 50% of children and adolescents with adrenocortical carcinoma (ACC), and of these, up to 50% relapse. We explored the five-item microscopic score and the pS-GRAS score for guiding management. Data from children and adolescents with COG stage II and III ACC registered in the MET studies were included. The five-item and pS-GRAS score were retrospectively calculated. By December 2021, 55 patients with stage II and III (stage II In patients with COG stage III, but not stage II, the five-item score affected EFS. Further studies are needed to identify patients at risk in COG stage II.
Sections du résumé
BACKGROUND
BACKGROUND
Locally advanced tumors account for approximately 50% of children and adolescents with adrenocortical carcinoma (ACC), and of these, up to 50% relapse. We explored the five-item microscopic score and the pS-GRAS score for guiding management.
METHODS
METHODS
Data from children and adolescents with COG stage II and III ACC registered in the MET studies were included. The five-item and pS-GRAS score were retrospectively calculated.
RESULTS
RESULTS
By December 2021, 55 patients with stage II and III (stage II
CONCLUSIONS
CONCLUSIONS
In patients with COG stage III, but not stage II, the five-item score affected EFS. Further studies are needed to identify patients at risk in COG stage II.
Identifiants
pubmed: 37686571
pii: cancers15174296
doi: 10.3390/cancers15174296
pmc: PMC10486626
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Kinderkrebsstiftung
ID : 2014.16, DKS 2017.16, DKS 2021.11
Organisme : W.A. Drenckmann Stiftung
ID : not applicable
Organisme : Mitteldeutsche Kinderkrebsstiftung
ID : not applicable
Organisme : Magdeburger Förderkreis krebskranker Kinder e.V.
ID : not applicable
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