Crystallization Selectivity of Ribavirin Solution and Amorphous Phase.
amorphous phase
crystallization selectivity
mid-frequency Raman difference spectra
ribavirin
solution
solvate
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
29 Aug 2023
29 Aug 2023
Historique:
received:
30
06
2023
revised:
22
08
2023
accepted:
25
08
2023
medline:
9
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Crystallization selectivity is an important principle in polymorph control. Ribavirin Form I, Form II, DMSO solvate, and amorphous ribavirin are prepared, and the short-range order similarities between these solid forms and ribavirin aqueous solution and DMSO solution are compared via mid-frequency Raman difference spectra (MFRDS). The crystallization process from amorphous ribavirin to Form I and from solution to amorphous phase is explained. Reasons for the difficulty in preparing the DMSO solvate are proposed. The rationale provided for the crystallization selectivity provides a foundation for the synthesis of metastable phases with a robust and convenient method.
Identifiants
pubmed: 37687147
pii: molecules28176320
doi: 10.3390/molecules28176320
pmc: PMC10488721
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 22005175
Organisme : Provincial Natural Science Foundation of Fujian
ID : 2023J011024, 2022J011176
Organisme : Education and Scientific Research on Young Teachers of Fujian
ID : JAT220349
Organisme : Open Project Program of the State Key Laboratory of Photocatalysis on Energy and Environment
ID : SKLPEE-KF202313
Organisme : Open Fund of Fujian Provincial Key Laboratory of Resources and Environment Monitoring & Sustainable Management and Utilization
ID : ZD1804
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