Aberrant resting-state functional connectivity underlies cognitive and functional impairments in remitted patients with bipolar disorder.
bipolar disorder
cognitive impairments
functional connectivity
psychological functioning
resting-state fMRI
Journal
Acta psychiatrica Scandinavica
ISSN: 1600-0447
Titre abrégé: Acta Psychiatr Scand
Pays: United States
ID NLM: 0370364
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
revised:
21
08
2023
received:
07
02
2023
accepted:
23
08
2023
medline:
22
11
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
ppublish
Résumé
Bipolar disorder (BD) is commonly associated with cognitive impairments, that directly contribute to patients' functional disability. However, there is no effective treatment targeting cognition in BD. A key reason for the lack of pro-cognitive interventions is the limited insight into the brain correlates of cognitive impairments in these patients. This is the first study investigating the resting-state neural underpinnings of cognitive impairments in different neurocognitive subgroups of patients with BD. Patients with BD in full or partial remission and healthy controls (final sample of n = 144 and n = 50, respectively) underwent neuropsychological assessment and resting-state functional magnetic resonance imaging. We classified the patients into cognitively impaired (n = 83) and cognitively normal (n = 61) subgroups using hierarchical cluster analysis of the four cognitive domains. We used independent component analysis (ICA) to investigate the differences between the neurocognitive subgroups and healthy controls in resting-state functional connectivity (rsFC) in the default mode network (DMN), executive central network (ECN), and frontoparietal network (FPN). Cognitively impaired patients displayed greater positive rsFC within the DMN and less negative rsFC within the ECN than healthy controls. Across cognitively impaired patients, lower positive connectivity within DMN and lower negative rsFC within ECN correlated with worse global cognitive performance. Cognitive impairments in BD seem to be associated with a hyper-connectivity within the DMN, which may explain the failure to suppress task-irrelevant DMN activity during the cognitive performance, and blunted anticorrelation in the ECN. Thus, aberrant connectivity within the DMN and ECN may serve as brain targets for pro-cognitive interventions.
Sections du résumé
BACKGROUND
Bipolar disorder (BD) is commonly associated with cognitive impairments, that directly contribute to patients' functional disability. However, there is no effective treatment targeting cognition in BD. A key reason for the lack of pro-cognitive interventions is the limited insight into the brain correlates of cognitive impairments in these patients. This is the first study investigating the resting-state neural underpinnings of cognitive impairments in different neurocognitive subgroups of patients with BD.
METHOD
Patients with BD in full or partial remission and healthy controls (final sample of n = 144 and n = 50, respectively) underwent neuropsychological assessment and resting-state functional magnetic resonance imaging. We classified the patients into cognitively impaired (n = 83) and cognitively normal (n = 61) subgroups using hierarchical cluster analysis of the four cognitive domains. We used independent component analysis (ICA) to investigate the differences between the neurocognitive subgroups and healthy controls in resting-state functional connectivity (rsFC) in the default mode network (DMN), executive central network (ECN), and frontoparietal network (FPN).
RESULTS
Cognitively impaired patients displayed greater positive rsFC within the DMN and less negative rsFC within the ECN than healthy controls. Across cognitively impaired patients, lower positive connectivity within DMN and lower negative rsFC within ECN correlated with worse global cognitive performance.
CONCLUSION
Cognitive impairments in BD seem to be associated with a hyper-connectivity within the DMN, which may explain the failure to suppress task-irrelevant DMN activity during the cognitive performance, and blunted anticorrelation in the ECN. Thus, aberrant connectivity within the DMN and ECN may serve as brain targets for pro-cognitive interventions.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
570-582Subventions
Organisme : Lundbeck Foundation Fellowship
ID : R215-2015-4121
Organisme : Instituto de Salud Carlos III - Subdirección General de Evaluación y Fomento de la Investigación: Miguel Servet Research Contract
ID : CPII19/0009
Organisme : PFIS contract
ID : FI20/00047
Organisme : Spanish Ministry of Science and Innovation
ID : PI18/00805
Organisme : Spanish Ministry of Science and Innovation
ID : PI15/00283
Organisme : ISCIII- Subdirección de Evaluación
Organisme : Fondo Europeo de Desarrollo Regional
Organisme : Instituto de Salud Carlos III; the CIBER of Mental Health
Organisme : Secretaria d'Universitats I Recerca del Departament d'Economia I Coneixement
ID : 2017 SGR 1365
Organisme : CERCA Programme
Organisme : Department de Salut de la Generalitat de Catalunya for the PERIS grant
ID : SLT006/17/00357
Informations de copyright
© 2023 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.
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