Glomerular microcirculation: Implications for diabetes, preeclampsia, and kidney injury.
RBC partitioning
blood flow heterogeneity
glomerular capillaries
juxtaglomerular apparatus
myogenic response
tubuloglomerular feedback
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
revised:
28
08
2023
received:
17
04
2023
accepted:
30
08
2023
pmc-release:
01
11
2024
medline:
27
10
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
ppublish
Résumé
This review outlines the features of tandem regulation of glomerular microcirculation by autoregulatory mechanisms and intraglomerular redistribution of blood flow. Multiple points of cooperation exist between autoregulatory and distributional mechanisms. Mutual interactions between myogenic and tubuloglomerular feedback (TGF) mechanisms regulating the inflow are briefly discussed. In addition to this, TGF operation involving purinergic, autocoid, and NO signaling affects, however, not only afferent arteriolar tone, but mesangial cell tone as well. The latter reversibly reconfigures the distribution of blood flow between the shorter and longer pathways in the glomerular tuft. I advance a hypothesis that blood flow in these pathways spontaneously alternates, and mesangial cell tonicity serves as a rheostatic shift between them. Furthermore, humoral messengers from macula densa cells, themselves dependent on myogenic mechanisms, fine-tune the secretion of renin and, subsequently, the local, intrarenal generation of angiotensin II, which, in turn, provides additional vasomotor signaling to glomerular capillaries through changing the tone of mesangial cells. This complex regulatory network may partially explain the phenomenon of renal functional reserve, as well as suggest implications for changes in renal function during pregnancy, early diabetes mellitus, and acute kidney injury.
Identifiants
pubmed: 37688412
doi: 10.1111/apha.14048
pmc: PMC10615779
mid: NIHMS1930345
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14048Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL144528
Pays : United States
Informations de copyright
© 2023 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.
Références
Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2687-96
pubmed: 15297253
Microvasc Res. 1999 May;57(3):298-309
pubmed: 10329256
Am J Physiol Renal Physiol. 2016 May 1;310(9):F832-45
pubmed: 26823282
Acta Physiol Scand. 1993 Mar;147(3):305-13
pubmed: 8386427
Am J Physiol Heart Circ Physiol. 2020 Sep 1;319(3):H661-H681
pubmed: 32762557
Kidney Int. 2006 Jul;70(1):157-64
pubmed: 16710351
J Am Soc Nephrol. 2021 Oct;32(10):2485-2500
pubmed: 34127535
Am J Physiol Renal Physiol. 2021 Mar 1;320(3):F492-F504
pubmed: 33491562
Physiology (Bethesda). 2005 Apr;20:102-11
pubmed: 15772299
Kidney Int. 1984 Jan;25(1):53-64
pubmed: 6587164
Annu Rev Physiol. 2011;73:377-99
pubmed: 20936939
Annu Rev Physiol. 2015;77:301-22
pubmed: 25668021
Am J Physiol Regul Integr Comp Physiol. 2020 Dec 1;319(6):R690-R702
pubmed: 33074016
Sci Rep. 2016 Nov 18;6:36763
pubmed: 27857165
Am J Physiol. 1977 Mar;232(3):F215-21
pubmed: 842668
J Biol Chem. 1999 Aug 27;274(35):25130-5
pubmed: 10455194
Front Endocrinol (Lausanne). 2022 May 19;13:872918
pubmed: 35663316
Endocr Rev. 2017 Apr 1;38(2):123-144
pubmed: 28323944
Am J Physiol Renal Physiol. 2006 Jun;290(6):F1507-15
pubmed: 16418302
Biorheology. 2019;56(1):1-13
pubmed: 30814342
Am J Physiol Renal Physiol. 2005 Feb;288(2):F298-307
pubmed: 15479856
J Am Soc Nephrol. 2007 May;18(5):1437-45
pubmed: 17389736
J Am Soc Nephrol. 2022 Sep;33(9):1641-1648
pubmed: 35853715
J Physiol. 1976 Mar;256(1):81-91
pubmed: 933069
Artif Organs. 2021 Sep;45(9):1083-1096
pubmed: 33590890
Physiol Rev. 2010 Apr;90(2):607-73
pubmed: 20393195
Acta Physiol (Oxf). 2021 Apr;231(4):e13592
pubmed: 33269519
Sci Rep. 2020 Nov 23;10(1):20334
pubmed: 33230129
Physiol Rev. 2015 Apr;95(2):405-511
pubmed: 25834230
J Am Soc Nephrol. 1993 Dec;4(6):1275-87
pubmed: 8130354
J Biol Chem. 2000 Dec 1;275(48):37922-9
pubmed: 10982805
Am J Physiol. 1986 Apr;250(4 Pt 2):F613-8
pubmed: 3963200
Am J Physiol. 1993 Jan;264(1 Pt 2):F166-74
pubmed: 8430827
Cardiovasc Eng Technol. 2011 Dec 1;2(4):349-360
pubmed: 23555330
Front Physiol. 2020 Sep 25;11:566273
pubmed: 33123027
JAMA Intern Med. 2018 Dec 1;178(12):1681-1690
pubmed: 30422153
Am J Physiol. 1994 May;266(5 Pt 2):H1822-8
pubmed: 8203581
Am J Physiol. 1992 Sep;263(3 Pt 2):F562-72
pubmed: 1415586
PLoS Comput Biol. 2019 Aug 30;15(8):e1007231
pubmed: 31469820
Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1370-F1384
pubmed: 29923763
Kidney Int. 1990 Nov;38(5):769-84
pubmed: 2266660
Pflugers Arch. 1976 Apr 6;362(3):229-40
pubmed: 944430
Am J Physiol Regul Integr Comp Physiol. 2006 May;290(5):R1153-67
pubmed: 16603656
Am J Physiol Renal Physiol. 2007 Oct;293(4):F1381-90
pubmed: 17699555
Am J Physiol. 1984 Jun;246(6 Pt 2):F897-906
pubmed: 6377913
Am J Physiol. 1994 Jul;267(1 Pt 2):F160-73
pubmed: 8048557
Acta Physiol Scand. 1988 Jun;133(2):149-57
pubmed: 3227911
Physiol Rev. 2023 Jan 1;103(1):787-854
pubmed: 36007181
Circulation. 2011 Jun 21;123(24):2856-69
pubmed: 21690502
Clin Sci. 1950;9(4):379-404
pubmed: 24540020
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4322-7
pubmed: 12655045
Am J Physiol Renal Physiol. 2002 Jul;283(1):F197-201
pubmed: 12060602
Adv Chronic Kidney Dis. 2020 Nov;27(6):449-454
pubmed: 33328060
Kidney Int. 2022 Mar;101(3):541-550
pubmed: 34843754
Am J Physiol Renal Physiol. 2013 May 1;304(9):F1181-6
pubmed: 23445620
Genome Med. 2023 Jan 10;15(1):2
pubmed: 36627643
Front Physiol. 2021 Nov 08;12:770450
pubmed: 34819877
Circ Res. 1994 Aug;75(2):357-68
pubmed: 8033345
Circ Res. 1990 Oct;67(4):826-34
pubmed: 2208609
Clin Sci (Lond). 1988 Jan;74(1):11-5
pubmed: 3338249
Am J Physiol. 1993 Mar;264(3 Pt 2):F427-34
pubmed: 8456956
Microvasc Res. 1973 Jan;5(1):34-48
pubmed: 4684755
Biochem J. 2009 Nov 11;424(2):221-31
pubmed: 19747166
Am J Physiol Renal Physiol. 2019 May 1;316(5):F769-F784
pubmed: 30759020
Am J Med. 1983 Dec;75(6):943-50
pubmed: 6650549
Pflugers Arch. 2013 Jan;465(1):39-51
pubmed: 22665048
Am J Physiol Renal Physiol. 2006 Aug;291(2):F473-80
pubmed: 16495210
Proc Soc Exp Biol Med. 1955 Aug;89(4):687-90
pubmed: 13254867
J Clin Invest. 2016 Dec 1;126(12):4527-4536
pubmed: 27797339