Both stronger and weaker cerebro-cerebellar functional connectivity patterns during processing of spoken sentences in autism spectrum disorder.
MEG
autism
cerebellum
functional connectivity
speech
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 12 2023
01 12 2023
Historique:
revised:
11
08
2023
received:
17
02
2023
accepted:
20
08
2023
medline:
2
11
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
ppublish
Résumé
Cerebellar differences have long been documented in autism spectrum disorder (ASD), yet the extent to which such differences might impact language processing in ASD remains unknown. To investigate this, we recorded brain activity with magnetoencephalography (MEG) while ASD and age-matched typically developing (TD) children passively processed spoken meaningful English and meaningless Jabberwocky sentences. Using a novel source localization approach that allows higher resolution MEG source localization of cerebellar activity, we found that, unlike TD children, ASD children showed no difference between evoked responses to meaningful versus meaningless sentences in right cerebellar lobule VI. ASD children also had atypically weak functional connectivity in the meaningful versus meaningless speech condition between right cerebellar lobule VI and several left-hemisphere sensorimotor and language regions in later time windows. In contrast, ASD children had atypically strong functional connectivity for in the meaningful versus meaningless speech condition between right cerebellar lobule VI and primary auditory cortical areas in an earlier time window. The atypical functional connectivity patterns in ASD correlated with ASD severity and the ability to inhibit involuntary attention. These findings align with a model where cerebro-cerebellar speech processing mechanisms in ASD are impacted by aberrant stimulus-driven attention, which could result from atypical temporal information and predictions of auditory sensory events by right cerebellar lobule VI.
Identifiants
pubmed: 37688547
doi: 10.1002/hbm.26478
pmc: PMC10619366
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5810-5827Subventions
Organisme : NICHD NIH HHS
ID : R01 HD073254
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117998
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI116517
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015989
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015890
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB030006
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104585
Pays : United States
Informations de copyright
© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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