The origin of brain malignancies at the blood-brain barrier.
Brain metastasis
Cancer
Circulating tumor cells
Extracellular matrix
Metastatic niche
Neurovascular unit
Organotropism
Pre-metastatic niche
Tumor microenvironment
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
09 Sep 2023
09 Sep 2023
Historique:
received:
17
05
2023
accepted:
22
08
2023
revised:
21
08
2023
medline:
11
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
epublish
Résumé
Despite improvements in extracranial therapy, survival rate for patients suffering from brain metastases remains very poor. This is coupled with the incidence of brain metastases continuing to rise. In this review, we focus on core contributions of the blood-brain barrier to the origin of brain metastases. We first provide an overview of the structure and function of the blood-brain barrier under physiological conditions. Next, we discuss the emerging idea of a pre-metastatic niche, namely that secreted factors and extracellular vesicles from a primary tumor site are able to travel through the circulation and prime the neurovasculature for metastatic invasion. We then consider the neurotropic mechanisms that circulating tumor cells possess or develop that facilitate disruption of the blood-brain barrier and survival in the brain's parenchyma. Finally, we compare and contrast brain metastases at the blood-brain barrier to the primary brain tumor, glioma, examining the process of vessel co-option that favors the survival and outgrowth of brain malignancies.
Identifiants
pubmed: 37688612
doi: 10.1007/s00018-023-04934-1
pii: 10.1007/s00018-023-04934-1
pmc: PMC10492883
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
282Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : A03
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1292/2
Organisme : Deutsche Forschungsgemeinschaft
ID : TP09
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHM 2159/4-1
Informations de copyright
© 2023. The Author(s).
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