Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders.
Inflammatory mediators
Neuroinflammation
Perioperative neurocognitive disorders (PNDs)
Systemic inflammation
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
ISSN: 1420-908X
Titre abrégé: Inflamm Res
Pays: Switzerland
ID NLM: 9508160
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
29
05
2023
accepted:
22
08
2023
revised:
20
08
2023
medline:
29
9
2023
pubmed:
9
9
2023
entrez:
9
9
2023
Statut:
ppublish
Résumé
Perioperative neurocognitive disorder (PND) is a common disorder following anesthesia and surgery, especially in the elderly. The complex cellular and molecular processes are involved in PND, but the underlying pathogenesis of which remains inconclusive due to conflicting data. A growing body of evidence has been shown that perioperative systemic inflammation plays important roles in the development of PND. We reviewed the relevant literature retrieved by a search in the PubMed database (on July 20, 2023). The search terms used were "delirium", "post operative cognitive dysfunction", "perioperative neurocognitive disorder", "inflammation" and "systemic", alone and in combination. All articles identified were English-language, full-text papers. The ones cited in the review are those that make a substantial contribution to the knowledge about systemic inflammation and PNDs. The aim of this review is to bring together the latest evidence for the understanding of how perioperative systemic inflammation mediates neuroinflammation and brain injury, how the inflammation is regulated and how we can translate these findings into prevention and/or treatment for PND.
Identifiants
pubmed: 37688642
doi: 10.1007/s00011-023-01792-2
pii: 10.1007/s00011-023-01792-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1895-1907Subventions
Organisme : National Natural Science Foundation of China
ID : 82270997
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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