Dual-action potential of cationic cryptides against infections and cancers.
cancer
cryptides
infectious disease
peptides
therapeutic agents
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
03
06
2023
revised:
18
08
2023
accepted:
04
09
2023
medline:
20
11
2023
pubmed:
10
9
2023
entrez:
9
9
2023
Statut:
ppublish
Résumé
Cryptides are a subfamily of bioactive peptides embedded latently in their parent proteins and have multiple biological functions. Cationic cryptides could be used as modern drugs in both infectious diseases and cancers because their mechanism of action is less likely to be affected by genetic mutations in the treated cells, therefore addressing a current unmet need in these two areas of medicine. In this review, we present the current understanding of cryptides, methods to mine them sustainably using available online databases and prediction tools, with a particular focus on their antimicrobial and anticancer potential, and their potential applicability in a clinical setting.
Identifiants
pubmed: 37689179
pii: S1359-6446(23)00280-5
doi: 10.1016/j.drudis.2023.103764
pii:
doi:
Substances chimiques
Peptides
0
Proteins
0
Anti-Infective Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103764Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.