Toxic effects and mechanisms of nanoplastics on embryonic brain development using brain organoids model.
Brain organoids
Embryonic development
Molecular mechanism
Nanoplastics
WNT signaling
Journal
The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500
Informations de publication
Date de publication:
15 Dec 2023
15 Dec 2023
Historique:
received:
31
05
2023
revised:
08
08
2023
accepted:
06
09
2023
medline:
6
11
2023
pubmed:
10
9
2023
entrez:
9
9
2023
Statut:
ppublish
Résumé
Nanoplastics can be easily absorbed into the human body through inhalation, ingestion, and skin contact due to their physicochemical property. Despite the numerous studies postulating the potential adverse effects of environmental exposure to nanoplastics on neurodevelopment, the effects of nanoplastics and their regulatory mechanisms have not been specifically elucidated. We focused on the toxic effects of nanoplastics on brain developmental processes by investigating their interactions with brain organoids. Our findings indicated that nanoplastics exposure caused cellular dysfunction and structural disorders. Nanoplastics adversely affected critical cells in brain organoids, resulting in the reduction of neural precursor cells and neuronal cells. The expression of neural cadherin was also inhibited, which might lead to impaired axonal extension and formation of synaptic connections. In addition, transcriptome sequencing was performed to study the effects of different concentrations of nanoplastics on the signaling pathway. The qRT-PCR analysis confirmed that nanoplastics exposure resulted in decreased expression of several genes related to the Wnt signaling pathway, suggesting that nanoplastics may adversely affect embryonic brain growth through the suppression of the expression of these genes. Our research findings shed light on the deleterious effects of nanoplastics on embryonic brain development and have significant implications for the field of environmental toxicology.
Identifiants
pubmed: 37689192
pii: S0048-9697(23)05538-9
doi: 10.1016/j.scitotenv.2023.166913
pii:
doi:
Substances chimiques
Microplastics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
166913Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Liqun Chen reports financial support was provided by National Key Research and Development Program of China. Liqun Chen reports financial support was provided by National Natural Science Foundation of China.