An integrated approach to evaluate the functional effects of disease-associated NMDA receptor variants.
Ca(2+) influx
Charge transfer
Disease-associated variants
Epilepsy
Fractional Ca(2+) currents
Mg(2+) block
NMDA receptor dynamics
Negative allosteric modulators
Pore blockers
Positive allosteric modulators
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
17
04
2023
revised:
30
06
2023
accepted:
31
08
2023
pubmed:
10
9
2023
medline:
10
9
2023
entrez:
9
9
2023
Statut:
ppublish
Résumé
The NMDA receptor (NMDAR) is a ubiquitously expressed glutamate-gated ion channel that plays key roles in brain development and function. Not surprisingly, a variety of disease-associated variants have been identified in genes encoding NMDAR subunits. A critical first step to assess whether these variants contribute to their associated disorder is to characterize their effect on receptor function. However, the complexity of NMDAR function makes this challenging, with many variants typically altering multiple functional properties. At synapses, NMDARs encode pre- and postsynaptic activity to carry a charge transfer that alters membrane excitability and a Ca
Identifiants
pubmed: 37689262
pii: S0028-3908(23)00293-9
doi: 10.1016/j.neuropharm.2023.109703
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109703Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.