Recombinant antigen 5 from Polybia paulista wasp venom (Hymenoptera, Vespidae): Antigen-specific antibody production and functional profile of CD4

Animals Mice Wasps / metabolism Wasp Venoms / metabolism Antibody Formation Allergens Anaphylaxis CD4-Positive T-Lymphocytes
Antigen 5 CD4(+) T cells Cytokines production Hymenoptera venom allergen Polybia paulista Specific immunoglobulin

Journal

Journal of immunological methods
ISSN: 1872-7905
Titre abrégé: J Immunol Methods
Pays: Netherlands
ID NLM: 1305440

Informations de publication

Date de publication:
11 2023
Historique:
received: 09 05 2023
revised: 04 09 2023
accepted: 05 09 2023
medline: 30 10 2023
pubmed: 10 9 2023
entrez: 9 9 2023
Statut: ppublish

Résumé

Polybia paulista is a neotropical social wasp related to severe accidents and allergic reactions cases, including anaphylaxis, in southeastern Brazil. Antigen 5 (Poly p 5) is a major allergenic protein from its venom with potential use for component-resolved diagnostic. Therefore, the previous characterization of the immune response profile triggered by Poly p 5 should be evaluated. Recombinant Poly p 5 (rPoly p 5) was used to sensitize BALB/c mice with six weekly intradermal doses, and the specific antibody production and the functional profile of CD4

Identifiants

DOI: 10.1016/j.jim.2023.113557 PMID: 37689389
pubmed: 37689389
pii: S0022-1759(23)00139-4
doi: 10.1016/j.jim.2023.113557
pii:
doi:

Substances chimiques

Wasp Venoms 0
Allergens 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113557

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

Isabela Oliveira Sandrini Assugeni (IOS)

Laboratory of Arthropods Molecular Biology (LBMA), Institute of Biosciences of Rio Claro, Department of Biology, São Paulo State University, Rio Claro, SP, Brazil.

Murilo Luiz Bazon (ML)

Laboratory of Arthropods Molecular Biology (LBMA), Institute of Biosciences of Rio Claro, Department of Biology, São Paulo State University, Rio Claro, SP, Brazil.

Lucas Machado Pinto (LM)

Laboratory of Arthropods Molecular Biology (LBMA), Institute of Biosciences of Rio Claro, Department of Biology, São Paulo State University, Rio Claro, SP, Brazil.

Leonardo Antônio Benedito Mainente (LAB)

Laboratory of Translational Immunology (LIT), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.

Márcia Regina Brochetto-Braga (MR)

Laboratory of Arthropods Molecular Biology (LBMA), Institute of Biosciences of Rio Claro, Department of Biology, São Paulo State University, Rio Claro, SP, Brazil.

Ricardo de Lima Zollner (R)

Laboratory of Translational Immunology (LIT), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.

Luís Gustavo Romani Fernandes (LGR)

Laboratory of Translational Immunology (LIT), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: luisgrf@unicamp.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Recombinant antigen 5 from Polybia paulista...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Recombinant antigen 5 from Polybia paulista...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Hymenoptera › Guêpes › Recombinant antigen 5 from Polybia paulista...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins d'arthropode › Venins de guêpe › Recombinant antigen 5 from Polybia paulista...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité active › Production d'anticorps › Recombinant antigen 5 from Polybia paulista...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Allergènes › Recombinant antigen 5 from Polybia paulista...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Anaphylaxie › Recombinant antigen 5 from Polybia paulista...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Recombinant antigen 5 from Polybia paulista...