Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism.
Journal
British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
14
06
2023
accepted:
18
08
2023
revised:
10
08
2023
medline:
16
11
2023
pubmed:
10
9
2023
entrez:
9
9
2023
Statut:
ppublish
Résumé
Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years have passed since its discovery as the leading cause of the cancer syndrome Hereditary leiomyomatosis and Renal Cell Carcinoma (HLRCC), it is still unclear how the loss of FH causes cancer in a tissue-specific manner and with such aggressive behaviour. It has been shown that FH loss, via the accumulation of FH substrate fumarate, activates a series of oncogenic cascades whose contribution to transformation is still under investigation. In this review, we will summarise these recent findings in an integrated fashion and put forward the case that understanding the biology of FH and how its mutations promote transformation will be vital to establish novel paradigms of oncometabolism.
Identifiants
pubmed: 37689804
doi: 10.1038/s41416-023-02412-w
pii: 10.1038/s41416-023-02412-w
pmc: PMC10645937
doi:
Substances chimiques
Fumarate Hydratase
EC 4.2.1.2
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1546-1557Subventions
Organisme : Cancer Research UK
ID : C51061/A27453
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
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