Bioactive Suture with Added Innate Defense Functionality for the Reduction of Bacterial Infection and Inflammation.
TCP-25
host defense peptides
polyglactin
surgical site infections
suture
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
09 Sep 2023
09 Sep 2023
Historique:
revised:
04
09
2023
received:
28
03
2023
pubmed:
10
9
2023
medline:
10
9
2023
entrez:
10
9
2023
Statut:
aheadofprint
Résumé
Surgical site infections (SSI) are a clinical and economic burden. Suture-associated SSI may develop when bacteria colonize the suture surface and form biofilms that are resistant to antibiotics. Thrombin-derived C-terminal peptide (TCP)-25 is a host defense peptide with a unique dual mode of action that can target both bacteria and the excessive inflammation induced by bacterial products. The peptide demonstrates therapeutic potential in preclinical in vivo wound infection models. In this study, the authors set out to explore whether TCP-25 can provide a new bioactive innate immune feature to hydrophilic polyglactin sutures (Vicryl). Using a combination of biochemical, biophysical, antibacterial, biofilm, and anti-inflammatory assays in vitro, in silico molecular modeling studies, along with experimental infection and inflammation models in mice, a proof-of-concept that TCP-25 can provide Vicryl sutures with a previously undisclosed host defense capacity, that enables targeting of bacteria, biofilms, and the accompanying inflammatory response, is shown.
Identifiants
pubmed: 37689972
doi: 10.1002/adhm.202300987
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300987Subventions
Organisme : Edvard Welanders Stiftelse and Finsenstiftelsen (HudFonden)
Organisme : Royal Physiographic Society
Organisme : Crafoord and Österlund Foundation
Organisme : Swedish Government Funds for Clinical Research (ALF)
Organisme : Swedish National Infrastructure for Biological Mass Spectrometry (BioMS)
Organisme : Alfred Österlunds Stiftelse
Organisme : Vetenskapsrådet
ID : 2017-02341,2020-02016
Organisme : Crafoordska Stiftelsen
Informations de copyright
© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
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