Biomineralized Polydopamine Nanoparticle-Based Sodium Alginate Hydrogels for Delivery of Anti-serine/Threonine Protein Kinase B-Rapidly Accelerated Fibrosarcoma siRNA for Metastatic Melanoma Therapy.
BRAF silencing
Ca2+ overload
biomineralized polydopamine nanoparticles
injectable hydrogels
metastatic melanoma therapy
photothermal effects
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
26 09 2023
26 09 2023
Historique:
medline:
27
9
2023
pubmed:
10
9
2023
entrez:
10
9
2023
Statut:
ppublish
Résumé
Malignant melanoma, as a highly aggressive skin cancer, is strongly associated with mutations in serine/threonine protein kinase B-RAF (BRAF, where RAF stands for rapidly accelerated fibrosarcoma). Targeted therapy with anti-BRAF small interfering RNA (siBRAF) represents a crucial aspect of metastatic melanoma treatment. In this study, an injectable hydrogel platform based on sodium alginate (SA), with multifunctions of photothermal and Ca
Identifiants
pubmed: 37690074
doi: 10.1021/acsnano.3c05563
doi:
Substances chimiques
RNA, Small Interfering
0
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
polydopamine
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Antibodies
0
Alginates
0
Threonine
2ZD004190S
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM