Risk assessment of parabens in a transcriptomics-based in vitro test.

Alternative testing strategies Developmental and reproductive toxicity Gene expression In vitro test Induced pluripotent stem cells Parabens Toxicogenomics Transcriptomics

Journal

Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276

Informations de publication

Date de publication:
01 Oct 2023
Historique:
received: 01 08 2023
accepted: 07 09 2023
pubmed: 11 9 2023
medline: 11 9 2023
entrez: 10 9 2023
Statut: ppublish

Résumé

Parabens have been used for decades as preservatives in food, drugs and cosmetics. The majority however, were banned in 2009 and 2014 leaving only methyl-, ethyl-, propyl-, and butyl-derivates available for subsequent use. Methyl- and propylparaben have been extensively tested in vivo, with no resulting evidence for developmental and reproductive toxicity (DART). In contrast, ethylparaben has not yet been tested for DART in animal experiments, and it is currently debated if additional animal studies are warranted. In order to perform a comparison of the four currently approved parabens, we used a previously established in vitro test based on human induced pluripotent stem cells (iPSC) that are exposed to test substances during their differentiation to neuroectodermal cells. EC

Identifiants

DOI: 10.1016/j.cbi.2023.110699 PMID: 37690743
pubmed: 37690743
pii: S0009-2797(23)00366-6
doi: 10.1016/j.cbi.2023.110699
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110699

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The parabens tested in this study were provided by Clariant Produkte (Deutschland) GmbH. Companies of the Clariant Group produce and market parabens, among other products. Susann Fayyaz and Reinhard Kreiling are employees of Clariant Produkte (Deutschland) GmbH.

Auteurs

Florian Seidel (F)

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany. Electronic address: Seidelf@ifado.de.

Franziska Kappenberg (F)

Department of Statistics, TU Dortmund University, Vogelpothsweg 87, 44227, Dortmund, Germany.

Susann Fayyaz (S)

Clariant Produkte (Deutschland) GmbH, Brüningstrasse 50, 65929, Frankfurt am Main, Germany.

Andreas Scholtz-Illigens (A)

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.

Anna Cherianidou (A)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Physiology, Working Group Sachinidis, Robert-Koch-Str. 39, 50931, Cologne, Germany.

Katharina Derksen (K)

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.

Patrick Nell (P)

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.

Rosemarie Marchan (R)

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.

Karolina Edlund (K)

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.

Marcel Leist (M)

In Vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Universitätsstr. 10, PO, Box M657, 78457, Konstanz, Germany.

Agapios Sachinidis (A)

University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Physiology, Working Group Sachinidis, Robert-Koch-Str. 39, 50931, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.

Jörg Rahnenführer (J)

Department of Statistics, TU Dortmund University, Vogelpothsweg 87, 44227, Dortmund, Germany.

Reinhard Kreiling (R)

Clariant Produkte (Deutschland) GmbH, Brüningstrasse 50, 65929, Frankfurt am Main, Germany.

Jan G Hengstler (JG)

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany. Electronic address: Hengstler@ifado.de.

Classifications MeSH