Silk Fibroin-Based Coatings for Pancreatin-Dependent Drug Delivery.

Enteric coating In vivo validation Pancreatin-dependent drug delivery Silk fibroin–polymethacrylate copolymers Triggered release

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
09 Sep 2023
Historique:
received: 31 03 2023
revised: 04 09 2023
accepted: 04 09 2023
pubmed: 11 9 2023
medline: 11 9 2023
entrez: 10 9 2023
Statut: aheadofprint

Résumé

Triggerable coatings, such as pH-responsive polymethacrylate copolymers, can be used to protect the active pharmaceutical ingredients contained within oral solid dosage forms from the acidic gastric environment and to facilitate drug delivery directly to the intestine. However, gastrointestinal pH can be highly variable, which can reduce delivery efficiency when using pH-responsive drug delivery technologies. We hypothesized that biomaterials susceptible to proteolysis could be used in combination with other triggerable polymers to develop novel enteric coatings. Bioinformatic analysis suggested that silk fibroin is selectively degradable by enzymes in the small intestine, including chymotrypsin, but resilient to gastric pepsin. Based on the analysis, we developed a silk fibroin-polymethacrylate copolymer coating for oral dosage forms. In vitro and in vivo studies demonstrated that capsules coated with this novel silk fibroin formulation enable pancreatin-dependent drug release. We believe that this novel formulation and extensions thereof have the potential to produce more effective and personalized oral drug delivery systems for vulnerable populations including patients that have impaired and highly variable intestinal physiology.

Identifiants

DOI: 10.1016/j.xphs.2023.09.001 PMID: 37690778
pubmed: 37690778
pii: S0022-3549(23)00364-7
doi: 10.1016/j.xphs.2023.09.001
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest C.S. is currently employed by Bayer pharmaceuticals and has been listed as a co-inventor on multiple patent applications for drug delivery systems.. D.R., R.L. and G.T. are co-inventors on multiple patent applications describing novel drug delivery systems and interactions between excipients and drugs. D.R. acts as a mentor for the German Accelerator Life Sciences and acts as a scientific consultant for pharmaceutical and biotechnology companies. Complete details of all relationships for profit and not for profit for G.T. can found at the following link: https://www.dropbox.com/sh/szi7vnr4a2ajb56/AABs5N5i0q9AfT1IqIJAE-T5a?dl=0. For a list of entities to which R.L. is involved, compensated or uncompensated, see https://www.dropbox.com/s/yc3xqb5s8s94v7x/Rev%20Langer%20COI.pdf?dl=0.

Auteurs

Natsuda Navamajiti (N)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Biomedical Engineering Research Center, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand.

Apolonia Gardner (A)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Ruonan Cao (R)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Engineering Science, University of Toronto, Toronto, ON M5S 2E4, Canada.

Yutaro Sugimoto (Y)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Materials Engineering, Faculty of Engineering, The University of Tokyo, Tokyo, 113-0032, Japan.

Jee Won Yang (JW)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91105, USA.

Aaron Lopes (A)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Nhi V Phan (NV)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Joy Collins (J)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Tiffany Hua (T)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Siriporn Damrongsakkul (S)

Biomedical Engineering Research Center, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand; Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand; Center of Excellence in Biomaterial Engineering in Medical and Health, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand.

Sorada Kanokpanont (S)

Biomedical Engineering Research Center, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand; Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand; Center of Excellence in Biomaterial Engineering in Medical and Health, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand.

Christoph Steiger (C)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Daniel Reker (D)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: daniel.reker@duke.edu.

Robert Langer (R)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: rlanger@mit.edu.

Giovanni Traverso (G)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: ctraverso@bwh.harvard.edu.

Classifications MeSH