New insights into the role of thrombospondin-1 in glioblastoma development.

Humans Glioblastoma / genetics Brain Neoplasms / genetics Tumor Microenvironment
Glioblastoma Thrombospondin Tumor invasion

Journal

Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332

Informations de publication

Date de publication:
01 Mar 2024
Historique:
received: 31 08 2023
revised: 05 09 2023
accepted: 06 09 2023
medline: 7 11 2023
pubmed: 11 9 2023
entrez: 10 9 2023
Statut: ppublish

Résumé

Glioblastoma (GB), the most malignant subtype of diffuse glioma, is highly aggressive, invasive and vascularized. Its median survival is still short even with maximum standard care. There is a need to identify potential new molecules and mechanisms, that are involved in the interactions of GB cells with the tumor microenvironment (TME), for therapeutic intervention. Thrombospondin-1 (TSP1) is a multi-faceted matricellular protein which plays a significant role in development, physiology and pathology including cancer. Recent studies have pinpoint an important role of TSP1 in GB development which will be summarized and discussed herein. We will discuss studies, mainly from preclinical research, which should lead to a deeper understanding of TSP1's role in GB development. We will also discuss some issues with regard to the use of this knowledge for the clinic.

Identifiants

DOI: 10.1016/j.semcdb.2023.09.001 PMID: 37690904
pubmed: 37690904
pii: S1084-9521(23)00165-9
doi: 10.1016/j.semcdb.2023.09.001
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

52-57

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest There is no conflict of interest to declare.

Auteurs

Andreas Bikfalvi (A)

Bordeaux University, INSERM, U1312 BRIC, Tumor and Vascular Biology Laboratory, F-33615 Pessac, France. Electronic address: andreas.bikfalvi@u-bordeaux.fr.

Joris Guyon (J)

Service de Pharmacologie médicale, CHU de Bordeaux, 33615 Bordeaux, France.

Thomas Daubon (T)

Bordeaux University, CNRS, IBGC, UMR 5095, F-33 077 Bordeaux, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New insights into the role of thrombospondin-1...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › New insights into the role of thrombospondin-1...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › New insights into the role of thrombospondin-1...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › New insights into the role of thrombospondin-1...