Exploration of 3-aryl pyrazole-tethered sulfamoyl carboxamides as carbonic anhydrase inhibitors.
hCA I and II
mtCA 1-3
pyrazole
sulfonamide
tuberculosis
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
17
08
2023
received:
05
06
2023
accepted:
18
08
2023
medline:
3
11
2023
pubmed:
11
9
2023
entrez:
10
9
2023
Statut:
ppublish
Résumé
Herein, we report the design and synthesis of two series of pyrazole-tethered sulfamoyl phenyl acetamides and pyrazole-tethered sulfamoyl phenyl benzamides. The synthesized compounds were investigated for inhibiting two human carbonic anhydrases, human carbonic anhydrases (hCA) I and II, and those of the bacterial pathogen Mycobacterium tuberculosis, mtCA 1-3. The results indicate that, among the synthesized compounds, pyrazoles with 4-aminobenzene sulfonamide were more selective toward hCA I and II over mtCAs, and compounds with 3-aminobenzene sulfonamide were selective toward mtCA 1-3 over hCA I, II. Compound 6g showed significant and selective inhibition toward hCA I and II, with K
Identifiants
pubmed: 37691073
doi: 10.1002/ardp.202300309
doi:
Substances chimiques
Carbonic Anhydrase Inhibitors
0
pyrazole
3QD5KJZ7ZJ
Carbonic Anhydrase II
EC 4.2.1.-
Carbonic Anhydrases
EC 4.2.1.1
Pyrazoles
0
Carbonic Anhydrase I
EC 4.2.1.-
Sulfonamides
0
Benzamides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300309Subventions
Organisme : Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India
Organisme : Italian Ministry for University and Research (MIUR) for financing this research
ID : project FISR2019_04819 BacCAD
Informations de copyright
© 2023 Deutsche Pharmazeutische Gesellschaft.
Références
World Health Organization. 2022. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022
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