A pilot study of alterations of the gut microbiome in canine chronic kidney disease.
chronic kidney disease
dog
dysbiosis
gut microbiome
proteolytic bacteria
saccharolytic bacteria
Journal
Frontiers in veterinary science
ISSN: 2297-1769
Titre abrégé: Front Vet Sci
Pays: Switzerland
ID NLM: 101666658
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
06
2023
accepted:
11
08
2023
medline:
11
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Gut dysbiosis has been noted in humans and animals with chronic kidney disease (CKD). However, little is known about the gut microbiome in canine patients with CKD. This study aimed to analyze and compare the gut microbiome profiles of healthy and CKD dogs, including differences in the gut microbiome between each CKD stage. The study was conducted on 29 client-owned dogs who underwent physical examination, complete blood count (CBC), serum biochemistry, and urinalysis. The gut microbiome profile of healthy dogs ( Significant differences were seen in the composition of the gut microbiome, with increased operational taxonomic units from the phylum Our study demonstrated that in dogs with CKD, the composition of the gut microbiome varied depending on the stage of CKD. Alterations in gut microbiome composition observed in CKD patients are characterized by an increase in proteolytic bacteria and a decrease in saccharolytic bacteria. These findings suggest specific gut microbiota could be targeted for clinical management of uremic dogs with CKD.
Identifiants
pubmed: 37691637
doi: 10.3389/fvets.2023.1241215
pmc: PMC10484476
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1241215Informations de copyright
Copyright © 2023 Kim, Kim and Kim.
Déclaration de conflit d'intérêts
S-MK was employed by KR Lab Bio Incorporation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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