Biomaterial-based scaffolds in promotion of cartilage regeneration: Recent advances and emerging applications.
Biomaterials
Cartilage
Osteoarthritis
RANKL
Regeneration
Scaffolds
Journal
Journal of orthopaedic translation
ISSN: 2214-031X
Titre abrégé: J Orthop Translat
Pays: Singapore
ID NLM: 101625127
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
08
06
2023
revised:
07
07
2023
accepted:
05
08
2023
medline:
11
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Osteoarthritis (OA) poses a significant burden for countless individuals, inflicting relentless pain and impairing their quality of life. Although traditional treatments for OA focus on pain management and surgical interventions, they often fall short of addressing the underlying cause of the disease. Fortunately, emerging biomaterial-based scaffolds offer hope for OA therapy, providing immense promise for cartilage regeneration in OA. These innovative scaffolds are ingeniously designed to provide support and mimic the intricate structure of the natural extracellular matrix, thus stimulating the regeneration of damaged cartilage. In this comprehensive review, we summarize and discuss current landscape of biomaterial-based scaffolds for cartilage regeneration in OA. Furthermore, we delve into the diverse range of biomaterials employed in their construction and explore the cutting-edge techniques utilized in their fabrication. By examining both preclinical and clinical studies, we aim to illuminate the remarkable versatility and untapped potential of biomaterial-based scaffolds in the context of OA. By thoroughly examining the current state of research and clinical studies, this review provides valuable insights that bridge the gap between scientific knowledge and practical application. This knowledge is crucial for clinicians and researchers who strive to develop innovative treatments that go beyond symptom management and directly target the underlying cause of OA. Through the comprehensive analysis and multidisciplinary approach, the review paves the way for the translation of scientific knowledge into practical applications, ultimately improving the lives of individuals suffering from OA and shaping the future of orthopedic medicine.
Identifiants
pubmed: 37691640
doi: 10.1016/j.jot.2023.08.006
pii: S2214-031X(23)00060-8
pmc: PMC10485599
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
54-62Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Stem Cell Res. 2020 Apr;44:101738
pubmed: 32109723
ACS Biomater Sci Eng. 2020 May 11;6(5):3154-3161
pubmed: 33463277
Cell Tissue Bank. 2019 Jun;20(2):209-220
pubmed: 30854603
Int J Mol Sci. 2018 Feb 22;19(2):
pubmed: 29470431
Osteoarthritis Cartilage. 2022 Feb;30(2):207-215
pubmed: 34801671
Acta Biomater. 2018 Aug;76:126-134
pubmed: 29908335
Bioact Mater. 2023 Apr 28;27:505-545
pubmed: 37180643
Biomaterials. 2021 Nov;278:121131
pubmed: 34543785
Crit Rev Eukaryot Gene Expr. 2018;28(4):343-348
pubmed: 30311583
Adv Mater. 2017 Aug;29(29):
pubmed: 28585319
Bioengineering (Basel). 2023 Apr 07;10(4):
pubmed: 37106640
Med Clin North Am. 2020 Mar;104(2):293-311
pubmed: 32035570
Nat Rev Rheumatol. 2015 Jan;11(1):21-34
pubmed: 25247412
Bone. 2023 Jun;171:116746
pubmed: 36965655
J Colloid Interface Sci. 2022 Jul;617:224-235
pubmed: 35276523
Biofabrication. 2019 Apr 26;11(3):035012
pubmed: 30921774
Int J Biol Macromol. 2023 May 31;238:124098
pubmed: 36948341
Bioact Mater. 2022 Aug 12;25:460-471
pubmed: 37056272
Acta Biomater. 2022 Sep 15;150:181-198
pubmed: 35896136
Front Immunol. 2021 Nov 29;12:773171
pubmed: 34912342
J Orthop Translat. 2021 Sep 29;30:82-92
pubmed: 34660198
Polymers (Basel). 2018 Oct 31;10(11):
pubmed: 30961139
Adv Sci (Weinh). 2022 May;9(16):e2200050
pubmed: 35322596
Adv Exp Med Biol. 2018;1058:31-52
pubmed: 29691816
J Biomed Mater Res B Appl Biomater. 2018 Feb;106(2):827-833
pubmed: 28387996
Regen Biomater. 2023 Mar 27;10:rbad032
pubmed: 37081861
Sci Transl Med. 2022 Jan 12;14(627):eabi7282
pubmed: 35020409
Acta Biomater. 2022 Jul 1;146:317-340
pubmed: 35533924
Biotechnol Rep (Amst). 2019 Oct 27;24:e00387
pubmed: 31799142
Acta Biomater. 2018 Jan;65:1-20
pubmed: 29128537
Adv Drug Deliv Rev. 2010 Sep 30;62(12):1167-74
pubmed: 20920540
ACS Biomater Sci Eng. 2020 Aug 10;6(8):4324-4336
pubmed: 33455185
Adv Healthc Mater. 2017 Nov;6(22):
pubmed: 28804984
Biomaterials. 2014 Oct;35(31):8829-8839
pubmed: 25047629
Acta Biomater. 2021 Oct 1;133:74-86
pubmed: 33823324
Semin Cancer Biol. 2020 Dec;67(Pt 1):12-23
pubmed: 32380234
Front Bioeng Biotechnol. 2022 Aug 22;10:987999
pubmed: 36072291
Adv Healthc Mater. 2020 Apr;9(7):e1901714
pubmed: 32125786
Int J Biol Macromol. 2022 Nov 30;221:1313-1324
pubmed: 36108749
Gene Ther. 2007 May;14(9):721-32
pubmed: 17315042
J Biomed Mater Res A. 2010 Dec 1;95(3):828-36
pubmed: 20824648
Stem Cells Int. 2018 Feb 20;2018:6594841
pubmed: 29535776
Biomaterials. 2012 Apr;33(10):2926-35
pubmed: 22257722
Sci Rep. 2019 Aug 19;9(1):12034
pubmed: 31427611
Acta Biomater. 2021 Jul 1;128:21-41
pubmed: 33905945
Biomaterials. 2021 Nov;278:121169
pubmed: 34626937
Biomater Sci. 2023 Jul 25;11(15):5095-5107
pubmed: 37305990
Regen Ther. 2021 Feb 05;16:63-72
pubmed: 33598507
Mol Pharm. 2011 Aug 1;8(4):994-1001
pubmed: 21500855
Int J Mol Sci. 2021 Mar 07;22(5):
pubmed: 33800057
Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:588-595
pubmed: 31029352
Biofabrication. 2022 Jan 24;14(2):
pubmed: 34883477
Small. 2022 Jan;18(1):e2104229
pubmed: 34791802
Biomaterials. 2020 Jan;226:119536
pubmed: 31648135
Curr Opin Pharmacol. 2018 Jun;40:74-80
pubmed: 29625333
Adv Mater. 2023 May;35(19):e2212300
pubmed: 36811203
Mil Med Res. 2023 Mar 28;10(1):16
pubmed: 36978167
ACS Appl Mater Interfaces. 2020 May 13;12(19):21470-21480
pubmed: 32314911
Stem Cell Rev Rep. 2023 Aug;19(6):1615-1634
pubmed: 37074547
Biomaterials. 2022 Jul;286:121544
pubmed: 35633592
Small. 2021 Dec;17(50):e2101741
pubmed: 34288410
Biomaterials. 2019 Jan;188:38-49
pubmed: 30321863
Curr Pharm Des. 2015;21(15):1979-90
pubmed: 25732662
ACS Appl Mater Interfaces. 2023 May 3;15(17):20625-20637
pubmed: 37078820
Tissue Eng Part B Rev. 2019 Jun;25(3):187-201
pubmed: 30608012
J Mater Chem B. 2019 Feb 21;7(7):1027-1044
pubmed: 32254770
Small. 2022 Sep;18(36):e2201869
pubmed: 35713246
Front Pharmacol. 2023 Apr 28;14:1154135
pubmed: 37188263
Polymers (Basel). 2018 Mar 08;10(3):
pubmed: 30966320
Cell Tissue Res. 2017 Oct;370(1):41-52
pubmed: 28364144
Pharmacol Res. 2023 Apr;190:106733
pubmed: 36931541
Adv Funct Mater. 2021 Aug 26;31(35):
pubmed: 34840547