Association of serum lipids with inflammatory bowel disease: a systematic review and meta-analysis.
Cronh’s disease
inflammatory bowel disease
meta-analysis
serum lipids
ulcerative disease
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
04
2023
accepted:
09
08
2023
medline:
11
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Serum lipid levels seem to be abnormal in Inflammatory bowel disease (IBD). However, the specific manifestation of abnormal serum lipid levels in IBD are heterogeneous among studies and have not been sufficiently determined yet. PubMed, EMBASE, and Cochrane Library databases were searched. Serum lipid levels were compared between IBD patients and Health individuals, Crohn's (CD) and ulcerative colitis (UC), active and inactive, mild and non-mild patients, respectively. Meta-analyses were performed by using a random-effect model. Weight mean difference (WMD) with 95% confidence intervals (CIs) were calculated. Overall, 53 studies were included. Compared with healthy controls, IBD patients had significantly lower TC (WMD = -0.506, 95%CI = -0.674 to -0.338, The overall level of serum lipids in IBD patients is lower than that of healthy individuals and is negatively associated with disease severity. https://www.crd.york.ac.uk/prospero/, identifier: CRD42022383885.
Sections du résumé
Background
UNASSIGNED
Serum lipid levels seem to be abnormal in Inflammatory bowel disease (IBD). However, the specific manifestation of abnormal serum lipid levels in IBD are heterogeneous among studies and have not been sufficiently determined yet.
Methods
UNASSIGNED
PubMed, EMBASE, and Cochrane Library databases were searched. Serum lipid levels were compared between IBD patients and Health individuals, Crohn's (CD) and ulcerative colitis (UC), active and inactive, mild and non-mild patients, respectively. Meta-analyses were performed by using a random-effect model. Weight mean difference (WMD) with 95% confidence intervals (CIs) were calculated.
Results
UNASSIGNED
Overall, 53 studies were included. Compared with healthy controls, IBD patients had significantly lower TC (WMD = -0.506, 95%CI = -0.674 to -0.338,
Conclusion
UNASSIGNED
The overall level of serum lipids in IBD patients is lower than that of healthy individuals and is negatively associated with disease severity.
Systematic review registration
UNASSIGNED
https://www.crd.york.ac.uk/prospero/, identifier: CRD42022383885.
Identifiants
pubmed: 37692785
doi: 10.3389/fmed.2023.1198988
pmc: PMC10484721
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1198988Informations de copyright
Copyright © 2023 Chen, Li, Hu, Xu, Lu, Zhu and Shen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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