Evolution of a globally unique SARS-CoV-2 Spike E484T monoclonal antibody escape mutation in a persistently infected, immunocompromised individual.
SARS-CoV-2
Spike protein
antibody escape
immunocompromised host
novel mutation
prolonged infection
Journal
Virus evolution
ISSN: 2057-1577
Titre abrégé: Virus Evol
Pays: England
ID NLM: 101664675
Informations de publication
Date de publication:
2023
2023
Historique:
received:
23
06
2022
revised:
29
09
2022
accepted:
04
11
2022
medline:
11
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Prolonged infections in immunocompromised individuals may be a source for novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants, particularly when both the immune system and antiviral therapy fail to clear the infection and enable within-host evolution. Here we describe a 486-day case of SARS-CoV-2 infection in an immunocompromised individual. Following monotherapy with the monoclonal antibody Bamlanivimab, the individual's virus acquired resistance, likely via the earliest known occurrence of Spike amino acid variant E484T. Recently, E484T has arisen again as a derivative of E484A in the Omicron Variant of Concern, supporting the hypothesis that prolonged infections can give rise to novel variants long before they become prevalent in the human population.
Identifiants
pubmed: 37692895
doi: 10.1093/ve/veac104
pii: veac104
pmc: PMC10491860
doi:
Types de publication
Journal Article
Langues
eng
Pagination
veac104Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM140935
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press.
Déclaration de conflit d'intérêts
We declare no conflicts of interest.
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