[Gastrointestinal stromal tumors: a retrospective study].
Tumeurs stromales gastro-intestinales: une étude rétrospective.
Gastrointestinal stromal tumors
diagnosis
progression
treatment
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
07
2022
accepted:
18
04
2023
medline:
12
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
although rare, gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract. The aim of this work is to study the clinical, paraclinical, therapeutic and evolutionary features of GIST. we conducted a descriptive retrospective, monocentric study (April 2017-April 2021) collecting data from the medical records of all patients with GIST treated at the medical oncology department of the University Hospital of Mostaganem. we collected data from the medical records of 23 patients, with a median age of 54.4 years, sex ratio 1.8, over a period of 4 years. Abdominal pain was the most frequent symptom (78.3%, n=18); 47.8% of patients (n=11) had a tumor in the small bowel. The diagnosis was made at an early stage in 69.6% of cases (n=16). Surgical treatment was performed in 20 of the 23 patients, 18 of whom with R0. Of the 15 operated patients with a localized tumor, 13 received adjuvant medical treatment (Imatinib). Disease progression was reported in three patients treated with imatinib, then 2 the diagnosis of GIST is mainly based on histology and immunohistochemistry, which is often not performed by our pathologists. Molecular biology makes it possible to predict the prognosis and consequently adapt the therapies. The outcome of patients with GIST is often favorable but marked by recurrences despite a supposedly curative treatment requiring prolonged monitoring.
Identifiants
pubmed: 37692978
doi: 10.11604/pamj.2023.45.97.36563
pii: PAMJ-45-97
pmc: PMC10491712
doi:
Substances chimiques
Imatinib Mesylate
8A1O1M485B
Types de publication
Case Reports
English Abstract
Langues
fre
Sous-ensembles de citation
IM
Pagination
97Informations de copyright
Copyright: Habib Zidane et al.
Déclaration de conflit d'intérêts
Les auteurs ne déclarent aucun conflit d´intérêts.
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