FOXC1 and FOXC2 maintain mitral valve endothelial cell junctions, extracellular matrix, and lymphatic vessels to prevent myxomatous degeneration.
FOXC1
FOXC2
endothelial cell-cell junctions
extracellular matrix
lymphatics
mitral valve
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
30 Aug 2023
30 Aug 2023
Historique:
pubmed:
11
9
2023
medline:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Mitral valve (MV) disease including myxomatous degeneration is the most common form of valvular heart disease with an age-dependent frequency. Genetic evidence indicates mutations of the transcription factor Adult mice carrying tamoxifen-inducible, endothelial cell (EC)-specific, compound EC-deletions of Our results indicate that
Sections du résumé
Background
UNASSIGNED
Mitral valve (MV) disease including myxomatous degeneration is the most common form of valvular heart disease with an age-dependent frequency. Genetic evidence indicates mutations of the transcription factor
Methods
UNASSIGNED
Adult mice carrying tamoxifen-inducible, endothelial cell (EC)-specific, compound
Results
UNASSIGNED
EC-deletions of
Conclusions
UNASSIGNED
Our results indicate that
Identifiants
pubmed: 37693499
doi: 10.1101/2023.08.30.555455
pmc: PMC10491158
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : P30 CA060553
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY034740
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144129
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL159976
Pays : United States