Assessment of Serum Fucose Level among Oral Squamous Cell Carcinoma Patients: A Case-Control Study.
Biomarker
OSCC
malignancy
Journal
Journal of pharmacy & bioallied sciences
ISSN: 0976-4879
Titre abrégé: J Pharm Bioallied Sci
Pays: India
ID NLM: 101537209
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
30
01
2023
revised:
04
02
2023
accepted:
08
02
2023
medline:
11
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
ppublish
Résumé
Serum glycoproteins, which are made up of various monosaccharides, are altered in malignancy, a disorder of cellular conduct. L-fucose, a methyl pentose that serves as the last sugar in the majority of plasma glycoproteins, is one of the monosaccharides. Numerous illness conditions and cancers have been linked to increased levels of protein-bound fucose. In the current study, the serum fucose levels of patients with oral squamous cell carcinoma (OSCC) and healthy individuals were assessed and compared. The present study included a total of 30 OSCC patients and 30 healthy controls. The Winzler method was used to estimate the serum L-fucose levels using a spectrophotometer (Spectronic 20, Thermo Fisher Scientific, USA). Age and sex had no effect on serum fucose levels. In contrast to healthy individuals, OSCC patients' mean serum fucose levels significantly increased. In conclusion, patients with OSCC can benefit from the use of serum fucose as an investigative biomarker.
Sections du résumé
Background
UNASSIGNED
Serum glycoproteins, which are made up of various monosaccharides, are altered in malignancy, a disorder of cellular conduct. L-fucose, a methyl pentose that serves as the last sugar in the majority of plasma glycoproteins, is one of the monosaccharides. Numerous illness conditions and cancers have been linked to increased levels of protein-bound fucose.
Materials and Methods
UNASSIGNED
In the current study, the serum fucose levels of patients with oral squamous cell carcinoma (OSCC) and healthy individuals were assessed and compared. The present study included a total of 30 OSCC patients and 30 healthy controls. The Winzler method was used to estimate the serum L-fucose levels using a spectrophotometer (Spectronic 20, Thermo Fisher Scientific, USA).
Results
UNASSIGNED
Age and sex had no effect on serum fucose levels. In contrast to healthy individuals, OSCC patients' mean serum fucose levels significantly increased. In conclusion, patients with OSCC can benefit from the use of serum fucose as an investigative biomarker.
Identifiants
pubmed: 37694091
doi: 10.4103/jpbs.jpbs_91_23
pii: JPBS-15-878
pmc: PMC10485465
doi:
Types de publication
Journal Article
Langues
eng
Pagination
S878-S880Informations de copyright
Copyright: © 2023 Journal of Pharmacy and Bioallied Sciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Glycoconj J. 1997 Aug;14(5):577-84
pubmed: 9298690
Immunology. 1987 Sep;62(1):75-80
pubmed: 3653928
Cancer Detect Prev. 1998;22(3):237-40
pubmed: 9618045
Cancer Lett. 1997 Dec 23;121(2):147-53
pubmed: 9570352
Asian Pac J Cancer Prev. 2015;16(17):7497-500
pubmed: 26625751
Cancer Res. 1995 Aug 15;55(16):3654-8
pubmed: 7627975
Cancer. 2008 Jul 15;113(2):336-46
pubmed: 18521898
Indian J Cancer. 2010 Oct-Dec;47(4):452-7
pubmed: 21131761
Anticancer Res. 1994 Mar-Apr;14(2B):747-51
pubmed: 8010734
Cancer Res. 1985 Nov;45(11 Pt 1):5505-11
pubmed: 4053024
Anticancer Res. 1990 Jul-Aug;10(4):1071-4
pubmed: 2382978
J Cancer Res Ther. 2011 Apr-Jun;7(2):143-7
pubmed: 21768700
Indian J Med Res. 1967 Apr;55(4):380-4
pubmed: 5596270