The association of aspartate transaminase-to-alanine transaminase ratio and metabolic syndrome among HIV patients in Sidama Region, South Ethiopia.
AST/ALT ratio
Ethiopia
HIV
Sidama Region
metabolic syndrome
Journal
SAGE open medicine
ISSN: 2050-3121
Titre abrégé: SAGE Open Med
Pays: England
ID NLM: 101624744
Informations de publication
Date de publication:
2023
2023
Historique:
received:
13
03
2023
accepted:
07
08
2023
medline:
11
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Studies on the association of the aspartate transaminase-to-alanine transaminase ratio with the metabolic syndrome and its components among HIV patients were scarce. This study aims to determine the association between the aspartate transaminase-to-alanine transaminase ratio and the metabolic syndrome and its components in adult HIV patients on highly active antiretroviral therapy. This was a cross-sectional study conducted on 302 HIV patients from January 15 to June 30, 2021. Sociodemographic, clinical, and anthropometric data were collected using a structured questionnaire. The patient's medical records were reviewed. Biochemical analysis was performed after 5 ml of venous blood was collected from each study participant. Metabolic syndrome was defined by the third report of the national cholesterol education program-adult treatment panel. Logistic regression was done to assess the association of MetS with the independent variables, and correlation analysis was performed to see the correlation of MetS components with the aspartate aminotransferase-to-alanine aminotransferase ratio. 302 HIV-positive patients on highly active antiretroviral therapy were included in this study, and 54.6% were female. The median and interquartile range of the age of the study participants were 41 (35-50) years. The prevalence of metabolic syndrome was 29.5% (confidence interval = 24.5-35.1). Chronic illness (Adjusted odds ratio = 4.8, confidence interval = 2.2-10.9) and aspartate aminotransferase-to-alanine aminotransferase ratio (adjusted odds ratio = 2.5, confidence interval = 1.4-4.4) were significantly associated with Metabolic syndrome among the study participants. The aspartate aminotransferase-to-alanine aminotransferase ratio was significantly correlated with blood pressure. This study found the existence of a significant association between the aspartate aminotransferase-to-alanine aminotransferase ratio and metabolic syndrome among HIV patients.
Identifiants
pubmed: 37694128
doi: 10.1177/20503121231196701
pii: 10.1177_20503121231196701
pmc: PMC10483979
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20503121231196701Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Diabetol Metab Syndr. 2018 Feb 21;10:10
pubmed: 29483948
Open Forum Infect Dis. 2023 May 03;10(6):ofad241
pubmed: 37351455
Diabetes Care. 2007 Jan;30(1):113-9
pubmed: 17192343
Pan Afr Med J. 2012;13:43
pubmed: 23330034
Eur J Clin Microbiol Infect Dis. 2003 Dec;22(12):731-6
pubmed: 14610658
Circulation. 2009 Oct 20;120(16):1640-5
pubmed: 19805654
Diabetes. 2001 Aug;50(8):1844-50
pubmed: 11473047
JAMA. 1987 Apr 24;257(16):2176-80
pubmed: 3560398
Metab Syndr Relat Disord. 2013 Aug;11(4):229-35
pubmed: 23451816
J Allergy (Cairo). 2013;2013:627384
pubmed: 24204385
Am J Gastroenterol. 2014 May;109(5):695-704
pubmed: 24642579
Diabetol Metab Syndr. 2023 Mar 28;15(1):61
pubmed: 36978109
Curr Med Res Opin. 2011 Jan;27(1):63-9
pubmed: 21091096
Arch Public Health. 2020 May 07;78:40
pubmed: 32399212
J Family Med Prim Care. 2015 Jan-Mar;4(1):45-52
pubmed: 25810989
Am J Gastroenterol. 1999 Apr;94(4):1018-22
pubmed: 10201476
Braz J Infect Dis. 2010 Mar-Apr;14(2):158-66
pubmed: 20563442
HIV AIDS (Auckl). 2018 Oct 11;10:181-192
pubmed: 30349400
Syst Rev. 2019 Jan 3;8(1):4
pubmed: 30606249
Int J Biol Sci. 2011;7(7):1003-15
pubmed: 21912508
Diabetes Metab Syndr. 2008 Sep;2(3):171-178
pubmed: 25147585
PLoS One. 2019 Jan 31;14(1):e0210969
pubmed: 30703130
Diabetes Metab Syndr. 2014 Apr-Jun;8(2):102-7
pubmed: 24907175
AIDS Patient Care STDS. 2016 Jan;30(1):4-10
pubmed: 26683587
AIDS. 2007 Jun 19;21(10):1301-8
pubmed: 17545706
Diabetes Metab Syndr Obes. 2019 Nov 18;12:2387-2394
pubmed: 31819564
Obes Res Clin Pract. 2014 Jan-Feb;8(1):e79-87
pubmed: 24548580
AIDS Res Treat. 2016;2016:1985452
pubmed: 27493798
AIDS Patient Care STDS. 2018 Jun;32(6):215-222
pubmed: 29851503
World J Clin Cases. 2015 Mar 16;3(3):285-92
pubmed: 25789301
Int J Endocrinol. 2017;2017:1613657
pubmed: 28392801
Braz J Infect Dis. 2010 May-Jun;14(3):256-63
pubmed: 20835509
Biomed Res Int. 2013;2013:760963
pubmed: 24175300
Curr HIV/AIDS Rep. 2014 Sep;11(3):271-8
pubmed: 25027062
Clin Med Insights Endocrinol Diabetes. 2022 Feb 24;15:11795514221078029
pubmed: 35237088
J Med Assoc Thai. 2012 Mar;95(3):444-51
pubmed: 22550846
PLoS One. 2016 Aug 25;11(8):e0161304
pubmed: 27560931
Sao Paulo Med J. 2007 Jul 5;125(4):205-9
pubmed: 17992389
Diabetes Metab Syndr Obes. 2015 Apr 15;8:197-206
pubmed: 25926749
Diabetes Metab Syndr. 2020 Sep - Oct;14(5):1551-1556
pubmed: 32947754
PLoS One. 2016 Mar 23;11(3):e0150970
pubmed: 27008536