Sterile triggers drive joint inflammation in TNF- and IL-1β-dependent mouse arthritis models.
arthritis
germ-free
gut-joint axis
intestinal inflammation
microbiome
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
revised:
21
08
2023
received:
09
03
2023
accepted:
22
08
2023
pubmed:
11
9
2023
medline:
11
9
2023
entrez:
11
9
2023
Statut:
ppublish
Résumé
Arthritis is the most common extra-intestinal complication in inflammatory bowel disease (IBD). Conversely, arthritis patients are at risk for developing IBD and often display subclinical gut inflammation. These observations suggest a shared disease etiology, commonly termed "the gut-joint-axis." The clinical association between gut and joint inflammation is further supported by the success of common therapeutic strategies and microbiota dysbiosis in both conditions. Most data, however, support a correlative relationship between gut and joint inflammation, while causative evidence is lacking. Using two independent transgenic mouse arthritis models, either TNF- or IL-1β dependent, we demonstrate that arthritis develops independently of the microbiota and intestinal inflammation, since both lines develop full-blown articular inflammation under germ-free conditions. In contrast, TNF-driven gut inflammation is fully rescued in germ-free conditions, indicating that the microbiota is driving TNF-induced gut inflammation. Together, our study demonstrates that although common inflammatory pathways may drive both gut and joint inflammation, the molecular triggers initiating such pathways are distinct in these tissues.
Identifiants
pubmed: 37694693
doi: 10.15252/emmm.202317691
pmc: PMC10565626
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e17691Subventions
Organisme : Fonds Wetenschappelijk Onderzoek (FWO)
ID : EOS-G0H2522N-40007505
Organisme : Foundation for Research in Rheumatology (FOREUM)
Organisme : UGent | Bijzonder Onderzoeksfonds UGent (BOF)
ID : GOA031-22BOF
Organisme : UGent | Bijzonder Onderzoeksfonds UGent (BOF)
ID : BOF-01N01019
Organisme : UGent | Bijzonder Onderzoeksfonds UGent (BOF)
ID : STA010-19BOF
Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
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