Limiting viral replication in hepatocytes alters Rift Valley fever virus disease manifestations.
Rift Valley fever virus
encephalitis
hepatitis
viral pathogenesis
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
28 09 2023
28 09 2023
Historique:
medline:
29
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
ppublish
Résumé
Rift Valley fever virus (RVFV) causes mild to severe disease in humans and livestock. Outbreaks of RVFV have been reported throughout Africa and have spread outside Africa since 2000, calling for urgent worldwide attention to this emerging virus. RVFV directly infects the liver, and elevated transaminases are a hallmark of severe RVFV infection. However, the specific contribution of viral replication in hepatocytes to pathogenesis of RVFV remains undefined. To address this, we generated a recombinant miRNA-targeted virus, RVFVmiR-122, to limit hepatocellular replication. MicroRNAs are evolutionarily conserved non-coding RNAs that regulate mRNA expression by targeting them for degradation. RVFVmiR-122 includes an insertion of four target sequences of the liver-specific miR-122. In contrast to control RVFVmiR-184, which contains four target sequences of mosquito-specific miR-184, RVFVmiR-122 has restricted replication
Identifiants
pubmed: 37695055
doi: 10.1128/jvi.00853-23
pmc: PMC10537571
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0085323Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK120531
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103645
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI049820
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001857
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
RNA Biol. 2012 Feb;9(2):137-42
pubmed: 22258222
PLoS Pathog. 2008 Jan;4(1):e13
pubmed: 18225953
J Virol. 1999 Jan;73(1):251-9
pubmed: 9847328
Am J Trop Med Hyg. 2010 Aug;83(2 Suppl):38-42
pubmed: 20682904
BMC Genomics. 2010 Feb 18;11:119
pubmed: 20167119
Cell. 2007 Jun 29;129(7):1401-14
pubmed: 17604727
Front Mol Neurosci. 2019 Jan 09;11:480
pubmed: 30686999
J Virol. 2013 May;87(9):4846-60
pubmed: 23408632
Nat Rev Immunol. 2020 Sep;20(9):537-551
pubmed: 32203325
Virus Res. 2012 Feb;163(2):417-23
pubmed: 22086058
Stem Cell Res Ther. 2019 Mar 29;10(1):112
pubmed: 30922384
Viruses. 2011 May;3(5):493-519
pubmed: 21666766
PLoS Negl Trop Dis. 2018 May 2;12(5):e0006463
pubmed: 29718912
Curr Biol. 2002 Apr 30;12(9):735-9
pubmed: 12007417
J Virol. 2021 Nov 9;95(23):e0150621
pubmed: 34495703
J Virol. 1995 Jul;69(7):3972-9
pubmed: 7769655
Virology. 1989 Jun;170(2):505-10
pubmed: 2728348
Am J Pathol. 2022 Sep;192(9):1259-1281
pubmed: 35718058
Virus Genes. 2019 Feb;55(1):1-11
pubmed: 30426314
Cell. 2021 Sep 30;184(20):5163-5178.e24
pubmed: 34559985
Microbiol Mol Biol Rev. 2006 Dec;70(4):1032-60
pubmed: 17158706
J Clin Invest. 2012 Aug;122(8):2871-83
pubmed: 22820288
Sci Rep. 2017 Oct 30;7(1):14385
pubmed: 29085037
PLoS Negl Trop Dis. 2013 Apr 04;7(4):e2156
pubmed: 23593523
PLoS Pathog. 2016 Feb 02;12(2):e1005437
pubmed: 26837067
PLoS Negl Trop Dis. 2022 Jan 24;16(1):e0009852
pubmed: 35073355
Front Microbiol. 2020 Aug 21;11:1962
pubmed: 32973712
Virology. 2010 Nov 25;407(2):256-67
pubmed: 20850165
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12117-22
pubmed: 22778433
Clin Infect Dis. 2003 Oct 15;37(8):1084-92
pubmed: 14523773
PLoS Pathog. 2012 Jan;8(1):e1002465
pubmed: 22241991
PLoS Pathog. 2009 Feb;5(2):e1000287
pubmed: 19197350
Virology. 2012 Jan 5;422(1):6-12
pubmed: 22018491
Ann Clin Microbiol Antimicrob. 2020 Jan 22;19(1):4
pubmed: 31969141
Nat Commun. 2016 May 19;7:11496
pubmed: 27193971
Nat Rev Mol Cell Biol. 2019 Jan;20(1):21-37
pubmed: 30108335
J Virol. 2014 Feb;88(4):2235-45
pubmed: 24335307
FEBS Lett. 2005 Oct 31;579(26):5911-22
pubmed: 16111679
J Gen Virol. 2019 Aug;100(8):1187-1199
pubmed: 31310198
Virology. 2007 Mar 15;359(2):459-65
pubmed: 17070883
PLoS Pathog. 2022 Jul 14;18(7):e1010649
pubmed: 35834486
J Virol. 2001 Feb;75(3):1371-7
pubmed: 11152510
Vaccines (Basel). 2022 Oct 25;10(11):
pubmed: 36366303
J Clin Invest. 2020 Mar 2;130(3):1466-1478
pubmed: 31794434
J Gen Virol. 1994 Jun;75 ( Pt 6):1345-52
pubmed: 7515937
Hepatology. 2016 Aug;64(2):599-615
pubmed: 27016325