Estimation of relative biological effectiveness of
RBE
Radiopharmaceutical therapy
[177Lu]Lu-PSMA
[225Ac]Ac-PSMA
mCRPC
Journal
EJNMMI physics
ISSN: 2197-7364
Titre abrégé: EJNMMI Phys
Pays: Germany
ID NLM: 101658952
Informations de publication
Date de publication:
11 Sep 2023
11 Sep 2023
Historique:
received:
21
03
2023
accepted:
07
08
2023
medline:
11
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Over recent years, [ This study employed the TOol for PArtcile Simulation (TOPAS) based on the Geant4 simulation toolkit. Simulation of the nuclear DNA and damage scoring were performed using the TOPAS-nBio extension of TOPAS. DNA repair was modeled utilizing the Python-based program MEDRAS (Mechanistic DNA Repair and Survival). Five different cell geometries of equal volume and two radionuclide internalization assumptions as well as two cell arrangement scenarios were investigated. The radionuclide activity (number of source points) was adopted based on SPECT images of patients undergoing the above-mentioned therapies. Based on the simulated dose-effect curves, the RBE of In this work, the consideration of DNA repair of the damage from [
Identifiants
pubmed: 37695374
doi: 10.1186/s40658-023-00567-2
pii: 10.1186/s40658-023-00567-2
pmc: PMC10495309
doi:
Types de publication
Journal Article
Langues
eng
Pagination
53Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : Research Training Group GRK 2274
Organisme : Bundesministerium für Bildung und Forschung
ID : 02NUK065C
Organisme : Bundesministerium für Bildung und Forschung
ID : 02NUK065C
Informations de copyright
© 2023. Springer Nature Switzerland AG.
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