The Influence of Sex Hormones and X Chromosome in Immune Responses.
Allergy and autoimmunity
Androgen receptor
Cancer immunity
Estrogen receptors
Organ-specific AID; MS; Systemic AID; SLE; Natural immunity
Sex differences
Sex steroid hormones
X chromosome inactivation escape
Journal
Current topics in microbiology and immunology
ISSN: 0070-217X
Titre abrégé: Curr Top Microbiol Immunol
Pays: Germany
ID NLM: 0110513
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
12
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
ppublish
Résumé
Males and females differ in their susceptibility to develop autoimmunity and allergy but also in their capacity to cope with infections and cancers. Cellular targets and molecular pathways underlying sexual dimorphism in immunity have started to emerge and appeared multifactorial. It became increasingly clear that sex-linked biological factors have important impact on the development, tissue maintenance and effector function acquisition of distinct immune cell populations, thereby regulating multiple layers of innate or adaptive immunity through distinct mechanisms. This review discusses the recent development in our understanding of the cell-intrinsic actions of biological factors linked to sex, sex hormones and sex chromosome complement, on immune cells, which may account for the sex differences in susceptibility to autoimmune diseases and allergies, and the sex-biased responses in natural immunity and cancer.
Identifiants
pubmed: 37695424
doi: 10.1007/978-3-031-35139-6_2
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-59Informations de copyright
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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