Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
06 11 2023
06 11 2023
Historique:
received:
16
01
2023
revised:
22
05
2023
accepted:
18
08
2023
medline:
12
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
ppublish
Résumé
Major histocompatibility complex (MHC) II is dynamically expressed on mucosal epithelial cells and is induced in response to inflammation and parasitic infections, upon exposure to microbiota, and is increased in chronic inflammatory diseases. However, the regulation of epithelial cell-specific MHC II during homeostasis is yet to be explored. We discovered a novel role for IL-22 in suppressing epithelial cell MHC II partially via the regulation of endoplasmic reticulum (ER) stress, using animals lacking the interleukin-22-receptor (IL-22RA1), primary human and murine intestinal and respiratory organoids, and murine models of respiratory virus infection or with intestinal epithelial cell defects. IL-22 directly downregulated interferon-γ-induced MHC II on primary epithelial cells by modulating the expression of MHC II antigen A α (H2-Aα) and Class II transactivator (Ciita), a master regulator of MHC II gene expression. IL-22RA1-knockouts have significantly higher MHC II expression on mucosal epithelial cells. Thus, while IL-22-based therapeutics improve pathology in chronic disease, their use may increase susceptibility to viral infections.
Identifiants
pubmed: 37695525
pii: 276249
doi: 10.1084/jem.20230106
pmc: PMC10494524
pii:
doi:
Substances chimiques
Interleukins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2023 Moniruzzaman et al.
Références
Immunity. 2008 Dec 19;29(6):947-57
pubmed: 19100701
Infect Immun. 2016 Jan 04;84(3):782-9
pubmed: 26729763
Nat Med. 2008 Mar;14(3):282-9
pubmed: 18264109
J Clin Invest. 2008 Feb;118(2):534-44
pubmed: 18172556
Immunity. 2023 May 9;56(5):1098-1114.e10
pubmed: 37003256
Curr Opin Immunol. 2015 Jun;34:22-7
pubmed: 25597442
Gut. 2011 Nov;60(11):1580-8
pubmed: 21252204
Front Immunol. 2018 Sep 25;9:2144
pubmed: 30319613
Nat Med. 2006 Nov;12(11):1301-9
pubmed: 17041596
Immunogenetics. 2019 Mar;71(3):171-187
pubmed: 30421030
Immunity. 2004 Aug;21(2):241-54
pubmed: 15308104
Respir Res. 2001;2(4):225-33
pubmed: 11686888
Immunology. 2021 Apr;162(4):357-367
pubmed: 32966619
Clin Pharmacol Ther. 2019 Jan;105(1):177-189
pubmed: 29952004
Immunity. 1997 Dec;7(6):861-71
pubmed: 9430231
J Immunol. 2008 Mar 15;180(6):4090-7
pubmed: 18322219
Gastroenterology. 2020 Oct;159(4):1342-1356.e6
pubmed: 32589883
BMC Immunol. 2009 Feb 16;10:10
pubmed: 19220912
Curr Opin Immunol. 2016 Jun;40:123-9
pubmed: 27115617
Gastroenterology. 2013 Feb;144(2):357-368.e9
pubmed: 23123183
Nature. 2015 Dec 24;528(7583):560-564
pubmed: 26649819
Int J Mol Sci. 2019 Jul 15;20(14):
pubmed: 31311100
J Immunol. 2011 Sep 1;187(5):2130-9
pubmed: 21795593
Cell. 2018 Nov 15;175(5):1307-1320.e22
pubmed: 30392957
Gut. 2020 Mar;69(3):578-590
pubmed: 31792136
J Exp Med. 2008 Mar 17;205(3):533-41
pubmed: 18332180
Nat Protoc. 2013 Dec;8(12):2471-82
pubmed: 24232249
J Neuroinflammation. 2020 Aug 25;17(1):249
pubmed: 32843067
Curr Opin Immunol. 2018 Jun;52:100-107
pubmed: 29754111
Gut. 2009 Feb;58(2):211-9
pubmed: 18832523
Gut Microbes. 2021 Jan-Dec;13(1):1-18
pubmed: 33645438
Int Immunopharmacol. 2004 May;4(5):669-77
pubmed: 15120651
Cell Mol Immunol. 2019 May;16(5):473-482
pubmed: 29670279
Nature. 2019 Feb;566(7743):249-253
pubmed: 30700914
J Virol. 2010 May;84(10):5007-14
pubmed: 20200252
Immunol Cell Biol. 2019 Apr;97(4):355-357
pubmed: 31012170
Mucosal Immunol. 2017 Mar;10(2):460-469
pubmed: 27220813
Gastroenterology. 2004 Jul;127(1):203-12
pubmed: 15236186
Cell. 2019 Jul 25;178(3):714-730.e22
pubmed: 31348891
J Immunol Res. 2017;2017:6104054
pubmed: 28316998
Mucosal Immunol. 2008 Sep;1(5):335-8
pubmed: 19079197
Am J Pathol. 2013 Apr;182(4):1286-96
pubmed: 23490254
J Clin Invest. 1998 Aug 15;102(4):792-803
pubmed: 9710448
Clin Transl Immunology. 2018 Apr 03;7(4):e1014
pubmed: 29632667
J Clin Invest. 1997 Jul 1;100(1):204-15
pubmed: 9202073
Science. 2015 May 29;348(6238):1031-5
pubmed: 25908663
Front Immunol. 2015 Sep 09;6:464
pubmed: 26441969
Nat Med. 2014 Dec;20(12):1417-26
pubmed: 25362253
Immunity. 2019 Nov 19;51(5):885-898.e7
pubmed: 31542340
Sci Rep. 2016 Jun 28;6:28990
pubmed: 27350069