Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.
SNARE
cell biology
dense core vesicle
mouse
neuropeptides
neuroscience
secretion
tomosyn
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
11 09 2023
11 09 2023
Historique:
received:
13
12
2022
accepted:
28
08
2023
medline:
13
9
2023
pubmed:
11
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. In the brain, tomosyn inhibits the fusion of synaptic vesicles (SVs), whereas its role in the fusion of neuropeptide-containing dense core vesicles (DCVs) is unknown. Here, we addressed this question using a new mouse model with a conditional deletion of tomosyn (
Identifiants
pubmed: 37695731
doi: 10.7554/eLife.85561
pii: 85561
pmc: PMC10495110
doi:
pii:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Nerve Tissue Proteins
0
R-SNARE Proteins
0
tomosyn protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023, Subkhangulova et al.
Déclaration de conflit d'intérêts
AS, MG, AG, Jv, AS, RT, MV No competing interests declared
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