Mining the ZINC database of natural products for specific, testosterone-like, OXER1 antagonists.
Docking simulations
G(αβγ) antagonists
GPCR
In vitro testing
Natural products
OXER1
QSAR analysis
ZINC04017374 (Naphthofluorescein)
ZINC08589130 (Puertogaline A)
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
04
07
2023
revised:
06
09
2023
accepted:
08
09
2023
pubmed:
12
9
2023
medline:
12
9
2023
entrez:
11
9
2023
Statut:
ppublish
Résumé
OXER1, the receptor for the oxidized arachidonic acid metabolite 5-oxo-ETE has been reported to play a significant role in inflammatory responses, being responsible for leucocyte chemotactic responses. Recently, we have identified OXER1 (GPR170) as a membrane receptor for androgens in prostate and breast cancer cells. Testosterone action via OXER1 induces specific Ca
Identifiants
pubmed: 37696380
pii: S0039-128X(23)00137-X
doi: 10.1016/j.steroids.2023.109309
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109309Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.