The complex biology of aryl hydrocarbon receptor activation in cancer and beyond.
AHR activation
AHR expression
AHRR
ARNT
Crosstalk with signaling pathways
DNA methylation
Degradation of AHR ligands
Epigenetic regulation
Interaction with transcription factors
Ligand diversity
Non-genomic AHR effects
Posttranslational modifications
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
03
07
2023
revised:
08
09
2023
accepted:
08
09
2023
medline:
2
10
2023
pubmed:
12
9
2023
entrez:
11
9
2023
Statut:
ppublish
Résumé
The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network that plays a critical role in various biological processes, including cellular metabolism, development, and immune responses. The complexity of AHR signaling arises from multiple factors, including the diverse ligands that activate the receptor, the expression level of AHR itself, and its interaction with the AHR nuclear translocator (ARNT). Additionally, the AHR crosstalks with the AHR repressor (AHRR) or other transcription factors and signaling pathways and it can also mediate non-genomic effects. Finally, posttranslational modifications of the AHR and its interaction partners, epigenetic regulation of AHR and its target genes, as well as AHR-mediated induction of enzymes that degrade AHR-activating ligands may contribute to the context-specificity of AHR activation. Understanding the complexity of AHR signaling is crucial for deciphering its physiological and pathological roles and developing therapeutic strategies targeting this pathway. Ongoing research continues to unravel the intricacies of AHR signaling, shedding light on the regulatory mechanisms controlling its diverse functions.
Identifiants
pubmed: 37696456
pii: S0006-2952(23)00389-1
doi: 10.1016/j.bcp.2023.115798
pmc: PMC10570930
pii:
doi:
Substances chimiques
Aryl Hydrocarbon Receptor Nuclear Translocator
138391-32-9
Receptors, Aryl Hydrocarbon
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115798Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest ST and CO are founders and CO is managing director of cAHRmeleon Bioscience GmbH. Authors of this manuscript have patents on AHR inhibitors in cancer (WO2013034685, CO); A method to multiplex tryptophan and its metabolites (WO2017072368, CO); A transcriptional signature to determine AHR activity (WO2020201825, ST, CO); Interleukin-4-induced gene 1 (IL4I1) as a biomarker (WO2020208190, ST, MTP, CO); Interleukin-4-induced gene 1 (IL4I1) and its metabolites as biomarkers for cancer (WO2021116357, ST, CO).
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