Prevalence of dementia and its association with central nervous system infections among older persons in northern Uganda: cross-sectional community-based study.
Central Nervous System infections
Dementia
Northern Uganda
Older persons
Journal
BMC geriatrics
ISSN: 1471-2318
Titre abrégé: BMC Geriatr
Pays: England
ID NLM: 100968548
Informations de publication
Date de publication:
11 09 2023
11 09 2023
Historique:
received:
08
06
2022
accepted:
15
07
2023
medline:
13
9
2023
pubmed:
12
9
2023
entrez:
11
9
2023
Statut:
epublish
Résumé
Dementia is a condition in which there is deterioration in cognitive function beyond what might be expected from the usual consequence of biological aging. Few studies have been conducted on the prevalence of dementia and its association with central nervous system (CNS) infections among older persons in African settings, particularly in Uganda. Therefore, this study assessed the prevalence of dementia and its association with CNS infections among older persons in Lira District, northern Uganda. This was a cross-sectional community-based study in Lira district northern Uganda. The study was conducted in March 2022 among 434 older persons aged 50 and above years who were selected by multistage sampling. Data were collected using an interviewer-administered questionnaire supplemented with information from participant's medical records and a brief community screening instrument for dementia. The instrument classifies dementia into unlikely, probable or possible dementia. Data were entered in duplicate into EpiData version 3.0, then transferred to Statistical Package for Social Sciences (SPSS) version 23 for statistical analysis. Our study found almost one in four (23%) of the older persons in Lira district northern Uganda were suffering from probable or possible dementia. Our study further found that older persons in Lira district northern Uganda with a positive history of central nervous system infections (CNS) had nearly five times higher odds of having probable or possible dementia compared to their counterparts (cOR: 4.5; 2.76-7.23; p ≤ 0.001). Being in advanced age of 70 + years (aOR: 2.6; 1.6-4.3; p ≤ 0.001), positive history of CNS infection particularly Herpes simplex virus-1 (aOR: 5.4; 1.4-20.5; p = 0.013), and chronic headache (aOR: 1.9; 1.1-3.1; p = 0.019) were independent predictors of probable or possible dementia among participants in this study. Dementia is a common condition among older persons in Lira district northern Uganda with a prevalence of 23% in our study. Older persons with a positive history of CNS infection had higher odd of developing dementia compared to their counterparts. Having advanced age, cerebral malaria, Herpes simplex virus - 1 (HSV-1) infections, and chronic headache were independent predictors for dementia. These results imply that health assessment for the risk of dementia should include screening for history of CNS conditions particularly cerebral malaria, HSV-1 and chronic headache.
Sections du résumé
BACKGROUND
Dementia is a condition in which there is deterioration in cognitive function beyond what might be expected from the usual consequence of biological aging. Few studies have been conducted on the prevalence of dementia and its association with central nervous system (CNS) infections among older persons in African settings, particularly in Uganda. Therefore, this study assessed the prevalence of dementia and its association with CNS infections among older persons in Lira District, northern Uganda.
METHODS
This was a cross-sectional community-based study in Lira district northern Uganda. The study was conducted in March 2022 among 434 older persons aged 50 and above years who were selected by multistage sampling. Data were collected using an interviewer-administered questionnaire supplemented with information from participant's medical records and a brief community screening instrument for dementia. The instrument classifies dementia into unlikely, probable or possible dementia. Data were entered in duplicate into EpiData version 3.0, then transferred to Statistical Package for Social Sciences (SPSS) version 23 for statistical analysis.
RESULTS
Our study found almost one in four (23%) of the older persons in Lira district northern Uganda were suffering from probable or possible dementia. Our study further found that older persons in Lira district northern Uganda with a positive history of central nervous system infections (CNS) had nearly five times higher odds of having probable or possible dementia compared to their counterparts (cOR: 4.5; 2.76-7.23; p ≤ 0.001). Being in advanced age of 70 + years (aOR: 2.6; 1.6-4.3; p ≤ 0.001), positive history of CNS infection particularly Herpes simplex virus-1 (aOR: 5.4; 1.4-20.5; p = 0.013), and chronic headache (aOR: 1.9; 1.1-3.1; p = 0.019) were independent predictors of probable or possible dementia among participants in this study.
CONCLUSION AND RECOMMENDATIONS
Dementia is a common condition among older persons in Lira district northern Uganda with a prevalence of 23% in our study. Older persons with a positive history of CNS infection had higher odd of developing dementia compared to their counterparts. Having advanced age, cerebral malaria, Herpes simplex virus - 1 (HSV-1) infections, and chronic headache were independent predictors for dementia. These results imply that health assessment for the risk of dementia should include screening for history of CNS conditions particularly cerebral malaria, HSV-1 and chronic headache.
Identifiants
pubmed: 37697266
doi: 10.1186/s12877-023-04174-9
pii: 10.1186/s12877-023-04174-9
pmc: PMC10496337
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
551Subventions
Organisme : FIC NIH HHS
ID : R25 TW011210
Pays : United States
Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Alzheimers Res Ther. 2020 Aug 7;12(1):94
pubmed: 32767997
Perspect Clin Res. 2017 Jul-Sep;8(3):148-151
pubmed: 28828311
Lancet Public Health. 2022 Feb;7(2):e105-e125
pubmed: 34998485
Int J Equity Health. 2017 Jul 20;16(1):129
pubmed: 28728553
Front Immunol. 2022 Jan 13;12:803475
pubmed: 35095888
J Biomed Sci. 2019 May 9;26(1):33
pubmed: 31072403
Indian J Psychiatry. 2009 Jan;51 Suppl 1:S52-5
pubmed: 21416018
J Headache Pain. 2018 Oct 11;19(1):95
pubmed: 30306350
Front Neurol. 2021 Mar 25;12:627761
pubmed: 33841302
Alzheimers Dement (N Y). 2021 Feb 14;7(1):e12119
pubmed: 33614892
Dement Geriatr Cogn Dis Extra. 2019 Apr 03;9(1):163-175
pubmed: 31097954
World Health Stat Q. 1991;44(3):98-106
pubmed: 1949887
Clin Interv Aging. 2021 Jul 22;16:1415-1425
pubmed: 34326633
BMC Health Serv Res. 2019 Dec 27;19(1):1005
pubmed: 31881885
Indian J Psychol Med. 2013 Apr;35(2):121-6
pubmed: 24049221
Front Cell Infect Microbiol. 2022 Feb 22;12:829413
pubmed: 35281436
BMC Geriatr. 2020 Feb 10;20(1):48
pubmed: 32041525
Front Cardiovasc Med. 2020 Jan 31;7:5
pubmed: 32083095
Alzheimers Dement. 2021 Mar;17(3):327-406
pubmed: 33756057
Alzheimers Dement (N Y). 2021 Jul 27;7(1):e12200
pubmed: 34337138
Cureus. 2021 Feb 17;13(2):e13398
pubmed: 33758699
Front Cell Neurosci. 2021 Nov 02;15:765217
pubmed: 34795562
Int J Geriatr Psychiatry. 2011 Sep;26(9):899-907
pubmed: 21845592
Chest. 2020 Jul;158(1S):S65-S71
pubmed: 32658654
Neurotherapeutics. 2018 Apr;15(2):417-429
pubmed: 29488144
Lancet Healthy Longev. 2021 Jul;2(7):e426-e435
pubmed: 34240064
Front Neurol. 2019 Feb 08;10:9
pubmed: 30800093
Front Aging Neurosci. 2022 Feb 11;14:804341
pubmed: 35221992