Late-life plasma proteins associated with prevalent and incident frailty: A proteomic analysis.

Humans Aged Frailty Proteomics Inflammation Syndrome Blood Proteins Frail Elderly
aging frailty late life proteomics

Journal

Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839

Informations de publication

Date de publication:
11 2023
Historique:
revised: 06 08 2023
received: 18 05 2023
accepted: 16 08 2023
medline: 17 11 2023
pubmed: 12 9 2023
entrez: 12 9 2023
Statut: ppublish

Résumé

Proteomic approaches have unique advantages in the identification of biological pathways that influence physical frailty, a multifactorial geriatric syndrome predictive of adverse health outcomes in older adults. To date, proteomic studies of frailty are scarce, and few evaluated prefrailty as a separate state or examined predictors of incident frailty. Using plasma proteins measured by 4955 SOMAmers in the Atherosclerosis Risk in Community study, we identified 134 and 179 proteins cross-sectionally associated with prefrailty and frailty, respectively, after Bonferroni correction (p < 1 × 10

Identifiants

DOI: 10.1111/acel.13975 PMID: 37697678 PMC: PMC10652348
pubmed: 37697678
doi: 10.1111/acel.13975
pmc: PMC10652348
doi:

Substances chimiques

Blood Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13975

Subventions

Organisme : NHLBI NIH HHS
ID : U01HL080295
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NIH HHS
ID : U01HL096814
Pays : United States
Organisme : NIA NIH HHS
ID : U01HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL134320
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC55222
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85086
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92022D00004
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG063507
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL152008
Pays : United States
Organisme : NIH HHS
ID : U01HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096814
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01HL130114
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92022D00001
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85081
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92022D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL080295
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL144483
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144483
Pays : United States
Organisme : NIH HHS
ID : U01HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132320
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG023629
Pays : United States
Organisme : NIH HHS
ID : U01HL096917
Pays : United States
Organisme : NIH HHS
ID : U01HL096902
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92022D00003
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92021D00006
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92022D00005
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85082
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148218
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85083
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL132320
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85079
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG023629
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134320
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85080
Pays : United States

Informations de copyright

© 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

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Auteurs

Fangyu Liu (F)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
ORCID: 0000-0003-1554-1478

Thomas R Austin (TR)

Department of Epidemiology, University of Washington, Seattle, Washington, USA.

Jennifer A Schrack (JA)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland, USA.

Jingsha Chen (J)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Jeremy Walston (J)

Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Rasika A Mathias (RA)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Morgan Grams (M)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Division of Precision Medicine, New York University Grossman School of Medicine, New York, New York, USA.

Michelle C Odden (MC)

Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, USA.
ORCID: 0000-0002-5974-3648

Anne Newman (A)

Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, Washington, USA.

Diego Ramonfaur (D)

Brigham and Women's Hospital, Harvard Medical School, Cardiovascular Medicine, Boston, Massachusetts, USA.

Amil M Shah (AM)

Brigham and Women's Hospital, Harvard Medical School, Cardiovascular Medicine, Boston, Massachusetts, USA.

B Gwen Windham (BG)

Department of Medicine, MIND Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Josef Coresh (J)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Keenan A Walker (KA)

Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Late-life plasma proteins associated with...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Late-life plasma proteins associated with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fragilité › Late-life plasma proteins associated with...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Late-life plasma proteins associated with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Late-life plasma proteins associated with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Maladie › Syndrome › Late-life plasma proteins associated with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Late-life plasma proteins associated with...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Personne âgée fragile › Late-life plasma proteins associated with...