Atypical fetal brain development in fetuses with non-syndromic isolated musculoskeletal birth defects (niMSBDs).
birth defects
fetal brain
fetus
prenatal brain development
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
14 10 2023
14 10 2023
Historique:
received:
15
05
2023
revised:
08
08
2023
accepted:
09
08
2023
pmc-release:
11
09
2024
medline:
9
11
2023
pubmed:
12
9
2023
entrez:
12
9
2023
Statut:
ppublish
Résumé
Non-syndromic, isolated musculoskeletal birth defects (niMSBDs) are among the leading causes of pediatric hospitalization. However, little is known about brain development in niMSBDs. Our study aimed to characterize prenatal brain development in fetuses with niMSBDs and identify altered brain regions compared to controls. We retrospectively analyzed in vivo structural T2-weighted MRIs of 99 fetuses (48 controls and 51 niMSBDs cases). For each group (19-31 and >31 gestational weeks (GW)), we conducted repeated-measures regression analysis with relative regional volume (% brain hemisphere) as a dependent variable (adjusted for age, side, and interactions). Between 19 and 31GW, fetuses with niMSBDs had a significantly (P < 0.001) smaller relative volume of the intermediate zone (-22.9 ± 3.2%) and cerebellum (-16.1 ± 3.5%,) and a larger relative volume of proliferative zones (38.3 ± 7.2%), the ganglionic eminence (34.8 ± 7.3%), and the ventricles (35.8 ± 8.0%). Between 32 and 37 GW, compared to the controls, niMSBDs showed significantly smaller volumes of central regions (-9.1 ± 2.1%) and larger volumes of the cortical plate. Our results suggest there is altered brain development in fetuses with niMSBDs compared to controls (13.1 ± 4.2%). Further basic and translational neuroscience research is needed to better visualize these differences and to characterize the altered development in fetuses with specific niMSBDs.
Identifiants
pubmed: 37697904
pii: 7267600
doi: 10.1093/cercor/bhad323
pmc: PMC10629896
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10793-10801Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB032366
Pays : United States
Organisme : NIH HHS
ID : S10 OD025111
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB031849
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB032708
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106030
Pays : United States
Organisme : NIH HHS
ID : R01NS106030
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD109395
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD100009
Pays : United States
Organisme : NIH HHS
ID : R01NS106030
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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