Shear wave elastography of tibial nerve in patients with diabetic peripheral neuropathy-A cross-sectional study.
Acoustic radiation force impulse imaging
Diabetic foot
Diabetic neuropathy
Elastography
Tibial neuropathy
Journal
Skeletal radiology
ISSN: 1432-2161
Titre abrégé: Skeletal Radiol
Pays: Germany
ID NLM: 7701953
Informations de publication
Date de publication:
12 Sep 2023
12 Sep 2023
Historique:
received:
02
07
2023
accepted:
31
08
2023
revised:
31
08
2023
medline:
12
9
2023
pubmed:
12
9
2023
entrez:
12
9
2023
Statut:
aheadofprint
Résumé
To explore the role of shear wave elastography of the tibial nerve as a potential ultrasonographic method for the diagnosis of tibial neuropathy in patients with type 2 diabetes. This cross-sectional study included 50 subjects each in case (patients with diabetic tibial neuropathy diagnosed on the basis of clinical features and nerve conduction study) and control groups (non-diabetic non-neuropathic healthy volunteers). The exclusion criteria included the presence of type 1 diabetes, a known history of neuropathy from other causes except for type 2 diabetes, or a history of leg or ankle fracture. Cross-sectional area and shear wave velocity values of the tibial nerve were measured in both groups. Demographic details and body mass index were obtained in both groups and additionally, the duration of type 2 diabetes and HbA1c values in the case group were also noted. Wilcoxon Mann-Whitney U test was used to compare these variables in study groups. ROC curve analysis provided additional findings. Tibial nerve stiffness was significantly higher in the case group (p-value < 0.001). The study groups did not significantly differ in the Cross-sectional area of the tibial nerve (p-value 0.57). The case group exhibited a higher frequency of loss of the fascicular pattern of the tibial nerve (40% vs 18%, p-value 0.027). Duration of diabetes mellitus and HbA1c values did not significantly affect Shear wave velocity values in the case group. At the cut-off value of Shear wave velocity of 3.13 m/s, sensitivity and specificity to diagnose diabetic peripheral neuropathy were 94% and 88% respectively. Increased nerve stiffness is seen in patients with diabetic peripheral neuropathy. Shear wave elastography might prove as a novel noninvasive technology for screening/early diagnosis of diabetic peripheral neuropathy.
Identifiants
pubmed: 37698625
doi: 10.1007/s00256-023-04448-8
pii: 10.1007/s00256-023-04448-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to International Skeletal Society (ISS).
Références
Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;1(183):109119.
doi: 10.1016/j.diabres.2021.109119
Ogurtsova K, Guariguata L, Barengo NC, et al. IDF diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021. Diabetes Res Clin Pract. 2022;1(183):109118.
doi: 10.1016/j.diabres.2021.109118
Kaneto H. Pathophysiology of type 2 diabetes mellitus. Nihon rinsho. Jpn J Clin Med. 2015;73(12):2003–7.
Yen FS, Wei JC, Shih YH, Hsu CC, Hwu CM. Impact of individual microvascular disease on the risks of macrovascular complications in type 2 diabetes: a nationwide population-based cohort study. Cardiovasc Diabetol. 2023;22(1):1–9.
doi: 10.1186/s12933-023-01821-8
Bandyk DF. The diabetic foot: Pathophysiology, evaluation, and treatment. Semin Vasc Surg. 2018;31(2–4):43–8.
doi: 10.1053/j.semvascsurg.2019.02.001
pubmed: 30876640
Vibha SP, Kulkarni MM, Kirthinath Ballala AB, Kamath A, Maiya GA. Community based study to assess the prevalence of diabetic foot syndrome and associated risk factors among people with diabetes mellitus. BMC Endocr Disord. 2018;18(1):1–9.
doi: 10.1186/s12902-018-0270-2
Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol. 2012;11(6):521–34.
doi: 10.1016/S1474-4422(12)70065-0
pubmed: 22608666
pmcid: 4254767
Won JC, Kim SS, Ko KS, Cha BY. Current status of diabetic peripheral neuropathy in Korea: report of a hospital-based study of type 2 diabetic patients in Korea by the diabetic neuropathy study group of the Korean diabetes association. Diabetes Metab J. 2014;38(1):25–31.
doi: 10.4093/dmj.2014.38.1.25
pubmed: 24627824
pmcid: 3950191
Cameron NE, Eaton SE, Cotter MA, Tesfaye S. Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia. 2001;44:1973–88.
doi: 10.1007/s001250100001
pubmed: 11719828
Malik RA, Tesfaye S, Thompson SD, et al. Endoneurial localisation of microvascular damage in human diabetic neuropathy. Diabetologia. 1993;36:454–9.
doi: 10.1007/BF00402283
pubmed: 8314451
Tesfaye S, Chaturvedi N, Eaton SE, et al. Vascular risk factors and diabetic neuropathy. N Engl J Med. 2005;352(4):341–50.
doi: 10.1056/NEJMoa032782
pubmed: 15673800
Kim RP, Edelman SV, Kim DD. Musculoskeletal complications of diabetes mellitus. Clin Diabetes. 2001;19(3):132–5.
doi: 10.2337/diaclin.19.3.132
Dikici AS, Ustabasioglu FE, Delil S, et al. Evaluation of the tibial nerve with shear-wave elastography: a potential sonographic method for the diagnosis of diabetic peripheral neuropathy. Radiology. 2017;282(2):494–501.
doi: 10.1148/radiol.2016160135
pubmed: 27643671
Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. Harrison’s principles of internal medicine, 21e. New York, NY, USA: Mcgraw-hill; 2022.
Dyck PJ, Overland CJ, Low PA, et al. NPhys Trial Investigators (see Appendix for additional authors).Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial. Muscle Nerve. 2010;42(2):157–64.
doi: 10.1002/mus.21661
pubmed: 20658599
Watanabe T, Ito H, Sekine A, et al. Sonographic evaluation of the peripheral nerve in diabetic patients: the relationship between nerve conduction studies, echo intensity, and cross-sectional area. J Ultrasound Med. 2010;29(5):697–708.
doi: 10.7863/jum.2010.29.5.697
pubmed: 20427781
Wei M, Ye X. Feasibility of point shear wave elastography for evaluating diabetic peripheral neuropathy. J Ultrasound Med. 2020;39(6):1135–41.
doi: 10.1002/jum.15198
pubmed: 31872909
Taljanovic MS, Gimber LH, Becker GW, et al. Shear-wave elastography: basic physics and musculoskeletal applications. Radiographics. 2017;37(3):855–70.
doi: 10.1148/rg.2017160116
pubmed: 28493799
He Y, Xiang X, Zhu BH, Qiu L. Shear wave elastography evaluation of the median and tibial nerve in diabetic peripheral neuropathy. Quant Imaging Med Surg. 2019;9(2):273.
doi: 10.21037/qims.2019.02.05
pubmed: 30976551
pmcid: 6414758
Chen R, Wang XL, Xue WL, et al. Application value of conventional ultrasound and real-time shear wave elastography in patients with type 2 diabetic polyneuropathy. Eur J Radiol. 2020;1(126):108965.
doi: 10.1016/j.ejrad.2020.108965
O’Shea A, Pierce TT. US elastography in hepatic fibrosis-radiology in training. Radiology. 2021;299(2):264–71.
Bedewi MA, Elsifey AA, Alfaifi T, et al. Shear wave elastography of the tibial nerve in healthy subjects. Medicine. 2021;100(3):e23999.
doi: 10.1097/MD.0000000000023999
pubmed: 33545992
pmcid: 7837829
Krouskop TA, Wheeler TM, Kallel F, Garra BS, Hall T. Elastic moduli of breast and prostate tissues under compression. Ultrason Imaging. 1998;20(4):260–74.
doi: 10.1177/016173469802000403
pubmed: 10197347
Wells PN, Liang HD. Medical ultrasound: imaging of soft tissue strain and elasticity. J R Soc Interface. 2011;8(64):1521–49.
doi: 10.1098/rsif.2011.0054
pubmed: 21680780
pmcid: 3177611
Ophir J, Cespedes I, Ponnekanti H, Yazdi Y, Li X. Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging. 1991;13(2):111–34.
doi: 10.1177/016173469101300201
pubmed: 1858217
Shiina T, Nightingale KR, Palmeri ML, et al. WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 1: basic principles and terminology. Ultrasound Med Biol. 2015;41(5):1126–47.
doi: 10.1016/j.ultrasmedbio.2015.03.009
pubmed: 25805059