Genomic associations with antibody response to an oral cholera vaccine.
4p14
4p16.1
6q23.3
Anti-lipopolysaccharide antibody response
Cholera vaccine
Genome-wide association study
TBC1D1
TBC1D14
TNFAIP3
Vibrio cholerae
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
06 10 2023
06 10 2023
Historique:
received:
08
08
2022
revised:
03
09
2023
accepted:
07
09
2023
medline:
3
10
2023
pubmed:
13
9
2023
entrez:
12
9
2023
Statut:
ppublish
Résumé
Oral cholera vaccine is one of the key interventions used in our fight to end the longest pandemic of our time, cholera. The immune response conferred by the currently available cholera vaccines, as measured by serum antibody levels, is variable amongst its recipients. We undertook a genome wide association study (GWAS) on antibody response to the cholera vaccine; globally, the first GWAS on cholera vaccine response. We identified three clusters of bi-allelic SNPs, in high within-cluster linkage disequilibrium that were moderately (p < 5 × 10
Identifiants
pubmed: 37699782
pii: S0264-410X(23)01084-8
doi: 10.1016/j.vaccine.2023.09.016
pii:
doi:
Substances chimiques
Cholera Vaccines
0
Antibodies, Bacterial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6391-6400Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.