Synthesis and cytotoxicity evaluation of novel 1,8-acridinedione derivatives bearing phthalimide moiety as potential antitumor agents.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 09 2023
12 09 2023
Historique:
received:
16
06
2023
accepted:
04
09
2023
medline:
14
9
2023
pubmed:
13
9
2023
entrez:
12
9
2023
Statut:
epublish
Résumé
In this study, we aimed to develop hybrid antitumor compounds by synthesizing and characterizing novel N-substituted acrididine-1,8-dione derivatives, designed as hybrids of phthalimide and acridine-1,8-diones. We employed a three-step synthetic strategy and characterized all compounds using IR,
Identifiants
pubmed: 37699954
doi: 10.1038/s41598-023-41970-0
pii: 10.1038/s41598-023-41970-0
pmc: PMC10497682
doi:
Substances chimiques
1,8-acridinedione
0
Tumor Suppressor Protein p53
0
Antineoplastic Agents
0
phthalimide
1J6PQ7YI80
Phthalimides
0
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15093Informations de copyright
© 2023. Springer Nature Limited.
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